MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03068nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
180730s20182018 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
0300-0664 |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1111/cen.13806 [doi] |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
29972703 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
The Effect of Lithium on the Progression Free and Overall Survival in Patients with Metastatic Differentiated Thyroid Cancer Undergoing Radioactive Iodine Therapy. |
| 251 ## - Source |
|---|
| Source |
Clinical Endocrinology. 2018 Jul 04 |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
Clin Endocrinol (Oxf). 2018 Jul 04 |
| 253 ## - Journal Name |
|---|
| Journal name |
Clinical endocrinology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Year |
2018 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2019 |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2018-07-30 |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
CONCLUSION: The older age is associated with shorter OS, while disease burden affects OS and PFS in patients with metastatic thyroid cancer. The method of preparation for RAI therapy does not affect the outcome. This article is protected by copyright. All rights reserved. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Copyright This article is protected by copyright. All rights reserved. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
DESIGN/PATIENTS/MEASUREMENTS: We performed a cohort study comparing overall survival (OS) and progression-free survival (PFS) between the three groups: THW(n=52), THW+Li (n=41) and rhTSH (n=42). Kaplan-Meier analyses were performed to compare OS and PFS between the groups. Cox proportional hazards regression model with a stepwise variable selection was performed to study the contribution of age, gender, histology, TNM status, a location of distant metastases and RAI dose. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
OBJECTIVE: Pretreatment with lithium (Li) is associated with an increased residence time of radioactive iodine (RAI) in differentiated thyroid cancer (DTC) metastases. There are no data translating this observation into long-term outcomes. The study goal was to compare the efficacy of three methods of preparation for RAI therapy in metastatic DTC - thyroid hormone withdrawal (THW), THW with pre-treatment with Li (THW+Li), and recombinant human TSH (rhTSH). |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESULTS: During the follow up of median 5.1 (IQR=3.0-8.1) years, 52% of patients had disease progression and 12.6% died. Although THW+Li group was characterized by the longest OS (p=0.007), only age (HR 1.05, CI 1.01-1.09, p=0.01) and widespread disease (HR3.8, CI 1.2-11.8, p=0.02) were found to affect OS in a multivariate model. There was no difference in PFS between the groups (p=0.47). Presence of distant metastases limited to the lungs only was associated with longer PFS (PFS HR 0.35, CI 0.20-0.60, p=0.0002). |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Medicine/Endocrinology |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Burman, Kenneth D |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Lima, Cristiane |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Wartofsky, Leonard |
| 790 ## - Authors |
|---|
| All authors |
Auh S, Burman K, Cochran C, Kebebew E, Klubo-Gwiezdzinska J, Lima C, Luo H, Reynolds J, Skarulis M, Tobey A, Wartofsky L, Zemskova M |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1111/cen.13806">https://dx.doi.org/10.1111/cen.13806</a> |
| Public note |
https://dx.doi.org/10.1111/cen.13806 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
