Differential Leukocyte Counts on Admission Predict Outcomes in Acute Ischemic Stroke Patients treated with Intravenous Thrombolysis. (Record no. 3606)

MARC details
000 -LEADER
fixed length control field 03641nam a22005297a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180730s20182018 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1351-5101
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1111/ene.13741 [doi]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 29953701
245 ## - TITLE STATEMENT
Title Differential Leukocyte Counts on Admission Predict Outcomes in Acute Ischemic Stroke Patients treated with Intravenous Thrombolysis.
251 ## - Source
Source European Journal of Neurology. 25(12):1417-1424, 2018 12.
252 ## - Abbreviated Source
Abbreviated source Eur J Neurol. 25(12):1417-1424, 2018 12.
253 ## - Journal Name
Journal name European journal of neurology
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2018
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2019
266 ## - Date added to catalog
Date added to catalog 2018-07-30
269 ## - Original dates
Original fiscal year FY2018
520 ## - SUMMARY, ETC.
Abstract CONCLUSIONS: Admission differential leukocyte counts are independently associated with clinical outcomes in AIS patients treated with IVT and might represent potential inflammatory targets for adjunctive neuroprotection in this stroke subgroup. This article is protected by copyright. All rights reserved.
520 ## - SUMMARY, ETC.
Abstract Copyright This article is protected by copyright. All rights reserved.
520 ## - SUMMARY, ETC.
Abstract METHODS: Consecutive AIS patients receiving IVT were evaluated at two stroke centers. Differential leukocyte counts and neutrophil-lymphocyte ratio (NLR) were determined during initial 12 hours of admission. Efficacy outcomes involved favorable functional outcome (FFO) [mRS-scores of 0-1] and functional independence (FI) [mRS-scores of 0-2] at three months; whereas safety outcomes were symptomatic intracranial hemorrhage (sICH) and three-month mortality.
520 ## - SUMMARY, ETC.
Abstract OBJECTIVE: To determine the association of differential leukocyte counts on admission with efficacy and safety outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT).
520 ## - SUMMARY, ETC.
Abstract RESULTS: Among 657 IVT-treated AIS patients, mean age was 64+/-14, 50% were female and median NIHSS was 7 points [IQR 4-13]. Lower neutrophil, leukocyte and NLR counts were observed in patients with 3-month FFO and FI, whereas higher counts were observed in patients who expired at three months. The best discriminative factor for 3-month FFO and FI were NLR<2.2 (sensitivity 51.4%, specificity 63.1%) and leukocyte <8,100/muL (sensitivity 57.5%, specificity 55.1%), respectively. After adjustment for potential confounders, NLR <2.2 was associated with higher odds of FFO (OR: 1.56; 95%CI: 1.08-2.24; p=0.018), leukocyte count <8,100/muL was associated with higher odds of 3-month FI (OR: 1.69; 95%CI: 1.11-2.57; p=0.014) and lower odds of 3-month mortality (OR: 0.31; 95%CI: 0.16-0.60; p=0.001), whereas combined neutrophil (<6,800/muL) and leukocyte (<8,100/muL) counts were associated with 3-month FI (OR: 1.73; 95%CI: 1.13-2.67; p=0.012).
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Brain Ischemia/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Fibrinolytic Agents/tu [Therapeutic Use]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Leukocyte Count
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Stroke/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Thrombolytic Therapy/mt [Methods]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Administration, Intravenous
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Brain Ischemia/dt [Drug Therapy]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hospitalization
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Prognosis
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Stroke/dt [Drug Therapy]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Treatment Outcome
656 ## - INDEX TERM--OCCUPATION
Department Critical Care Medicine
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Chang, Jason J
790 ## - Authors
All authors Alexandrov AV, Broce M, Chang JJ, Goyal N, Kerro A, Malhotra K, Pandhi A, Shahripour RB, Tsivgoulis G
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1111/ene.13741">https://dx.doi.org/10.1111/ene.13741</a>
Public note https://dx.doi.org/10.1111/ene.13741
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 07/30/2018   29953701 29953701 07/30/2018 07/30/2018 Journal Article

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