MARC details
000 -LEADER |
fixed length control field |
03641nam a22005297a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
180730s20182018 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
1351-5101 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1111/ene.13741 [doi] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
29953701 |
245 ## - TITLE STATEMENT |
Title |
Differential Leukocyte Counts on Admission Predict Outcomes in Acute Ischemic Stroke Patients treated with Intravenous Thrombolysis. |
251 ## - Source |
Source |
European Journal of Neurology. 25(12):1417-1424, 2018 12. |
252 ## - Abbreviated Source |
Abbreviated source |
Eur J Neurol. 25(12):1417-1424, 2018 12. |
253 ## - Journal Name |
Journal name |
European journal of neurology |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2018 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2019 |
266 ## - Date added to catalog |
Date added to catalog |
2018-07-30 |
269 ## - Original dates |
Original fiscal year |
FY2018 |
520 ## - SUMMARY, ETC. |
Abstract |
CONCLUSIONS: Admission differential leukocyte counts are independently associated with clinical outcomes in AIS patients treated with IVT and might represent potential inflammatory targets for adjunctive neuroprotection in this stroke subgroup. This article is protected by copyright. All rights reserved. |
520 ## - SUMMARY, ETC. |
Abstract |
Copyright This article is protected by copyright. All rights reserved. |
520 ## - SUMMARY, ETC. |
Abstract |
METHODS: Consecutive AIS patients receiving IVT were evaluated at two stroke centers. Differential leukocyte counts and neutrophil-lymphocyte ratio (NLR) were determined during initial 12 hours of admission. Efficacy outcomes involved favorable functional outcome (FFO) [mRS-scores of 0-1] and functional independence (FI) [mRS-scores of 0-2] at three months; whereas safety outcomes were symptomatic intracranial hemorrhage (sICH) and three-month mortality. |
520 ## - SUMMARY, ETC. |
Abstract |
OBJECTIVE: To determine the association of differential leukocyte counts on admission with efficacy and safety outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT). |
520 ## - SUMMARY, ETC. |
Abstract |
RESULTS: Among 657 IVT-treated AIS patients, mean age was 64+/-14, 50% were female and median NIHSS was 7 points [IQR 4-13]. Lower neutrophil, leukocyte and NLR counts were observed in patients with 3-month FFO and FI, whereas higher counts were observed in patients who expired at three months. The best discriminative factor for 3-month FFO and FI were NLR<2.2 (sensitivity 51.4%, specificity 63.1%) and leukocyte <8,100/muL (sensitivity 57.5%, specificity 55.1%), respectively. After adjustment for potential confounders, NLR <2.2 was associated with higher odds of FFO (OR: 1.56; 95%CI: 1.08-2.24; p=0.018), leukocyte count <8,100/muL was associated with higher odds of 3-month FI (OR: 1.69; 95%CI: 1.11-2.57; p=0.014) and lower odds of 3-month mortality (OR: 0.31; 95%CI: 0.16-0.60; p=0.001), whereas combined neutrophil (<6,800/muL) and leukocyte (<8,100/muL) counts were associated with 3-month FI (OR: 1.73; 95%CI: 1.13-2.67; p=0.012). |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Brain Ischemia/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Fibrinolytic Agents/tu [Therapeutic Use] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Leukocyte Count |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Stroke/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Thrombolytic Therapy/mt [Methods] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Administration, Intravenous |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Brain Ischemia/dt [Drug Therapy] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Female |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Hospitalization |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Male |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Middle Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Prognosis |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Stroke/dt [Drug Therapy] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Treatment Outcome |
656 ## - INDEX TERM--OCCUPATION |
Department |
Critical Care Medicine |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Chang, Jason J |
790 ## - Authors |
All authors |
Alexandrov AV, Broce M, Chang JJ, Goyal N, Kerro A, Malhotra K, Pandhi A, Shahripour RB, Tsivgoulis G |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1111/ene.13741">https://dx.doi.org/10.1111/ene.13741</a> |
Public note |
https://dx.doi.org/10.1111/ene.13741 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |