Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. (Record no. 3643)
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fixed length control field | 02796nam a22003617a 4500 |
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fixed length control field | 180818s20182018 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
International Standard Serial Number | 2472-1972 |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | 10.1210/js.2018-00132 [doi] |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | js_201800132 [pii] |
024 ## - OTHER STANDARD IDENTIFIER | |
Standard number or code | PMC6065485 [pmc] |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
PMID | 30087949 |
245 ## - TITLE STATEMENT | |
Title | Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. |
251 ## - Source | |
Source | Journal of the Endocrine Society. 2(8):944-948, 2018 Aug 01. |
252 ## - Abbreviated Source | |
Abbreviated source | J. endocr. soc.. 2(8):944-948, 2018 Aug 01. |
253 ## - Journal Name | |
Journal name | Journal of the Endocrine Society |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Year | 2018 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Manufacturer | FY2019 |
266 ## - Date added to catalog | |
Date added to catalog | 2018-08-16 |
520 ## - SUMMARY, ETC. | |
Abstract | Struma ovarii is a rare ovarian teratoma predominantly composed of thyroid tissue. The simultaneous presence of thyroid carcinoma in the struma ovarii and the thyroid gland is extremely rare. It remains unclear if these carcinomas represent independent primary tumors and whether the molecular mechanisms of the tumors developing in the thyroid and ovarian tissues are similar. We present the case of a patient with two independent papillary thyroid carcinomas (PTCs) in struma ovarii and the thyroid gland that are driven by different RAS mutations. A 62-year-old woman with a history of chronic lymphocytic leukemia/small lymphocytic lymphoma was diagnosed with a pelvic mass during a CT scan. She had surgery that included removal of her ovaries. A 7.2-cm classical variant of PTC arising in a struma ovarii was identified in the right ovary. Two months after the pelvic surgery, total thyroidectomy was performed, and a small nodule (0.8 cm) in the left lobe was diagnosed as a classical variant of PTC. Molecular analysis of tissues obtained from both the malignant struma ovarii and thyroid gland was performed. RAS mutations both in the PTC located in the thyroid and ovarian tissues were identified. However, whereas the thyroid gland tumor showed an HRAS Q61R mutation, the PTC in struma ovarii harbored an NRAS Q61R mutation. In this case, the finding of distinct types of RAS point mutation in thyroid cancers at two different locations provides definitive evidence that these cancers are synchronously developed independent primary tumors. |
546 ## - LANGUAGE NOTE | |
Language note | English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Health Research Institute |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
Institution | MedStar Washington Hospital Center |
656 ## - INDEX TERM--OCCUPATION | |
Department | Medicine/Endocrinology |
657 ## - INDEX TERM--FUNCTION | |
Medline publication type | Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Burman, Kenneth D |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Gomes-Lima, Cristiane J |
700 ## - ADDED ENTRY--PERSONAL NAME | |
Local Authors | Lee, Wen |
790 ## - Authors | |
All authors | Burman KD, Gomes-Lima CJ, Lee W, Nikiforov YE |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
DOI | <a href="https://dx.doi.org/10.1210/js.2018-00132">https://dx.doi.org/10.1210/js.2018-00132</a> |
Public note | https://dx.doi.org/10.1210/js.2018-00132 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Koha item type | Journal Article |
Item type description | Article |
Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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MedStar Authors Catalog | MedStar Authors Catalog | 08/16/2018 | 30087949 | 30087949 | 08/16/2018 | 08/16/2018 | Journal Article |