Mechanisms underlying the J-curve for diastolic blood pressure: Subclinical myocardial injury and immune activation. (Record no. 3723)

MARC details
000 -LEADER
fixed length control field 03612nam a22005777a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180928s20192019 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0167-5273
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.ijcard.2018.09.028 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S0167-5273(18)31876-X [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 30217423
245 ## - TITLE STATEMENT
Title Mechanisms underlying the J-curve for diastolic blood pressure: Subclinical myocardial injury and immune activation.
251 ## - Source
Source International Journal of Cardiology. 276:255-260, 2019 Feb 01.
252 ## - Abbreviated Source
Abbreviated source Int J Cardiol. 276:255-260, 2019 Feb 01.
253 ## - Journal Name
Journal name International journal of cardiology
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2019
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2019
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status aheadofprint
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
266 ## - Date added to catalog
Date added to catalog 2018-09-28
520 ## - SUMMARY, ETC.
Abstract BACKGROUND: Low diastolic blood pressure (DBP) is associated with increased risk of cardiovascular events. In patients with coronary artery disease (CAD), limitations in coronary blood flow and immune activity are implicated mechanisms, but evidence is lacking. We investigated the association between DBP, biomarkers of myocardial injury, inflammation, immune activation and incident events in patients with CAD.
520 ## - SUMMARY, ETC.
Abstract CONCLUSION: In patients with CAD, DBP<60mmHg is associated with subclinical myocardial injury, immune/inflammatory dysregulation and incident events. Aggressive BP control may be harmful in these patients, and further investigation is warranted to determine appropriate BP targets in patients with CAD.
520 ## - SUMMARY, ETC.
Abstract Copyright (c) 2018. Published by Elsevier B.V.
520 ## - SUMMARY, ETC.
Abstract METHODS: We studied 2448 adults (mean age 65+/-12years, 68% male, median follow-up 4.5years) with CAD. DBP was categorized into 10mmHg increments. Biomarkers of myocardial injury (high sensitivity cardiac troponin-I [hs-cTnI]) and immune activity/inflammation (soluble urokinase plasminogen activator receptor [suPAR]) were dichotomized at their median values. DBP 70-79mmHg was used as the referent group, and individuals were followed prospectively for adverse outcomes.
520 ## - SUMMARY, ETC.
Abstract RESULTS: After adjusting for demographic and clinical covariates, individuals with DBP<60mmHg had increased odds of elevated levels of hs-cTnI (OR=1.68; 95% CI=1.07, 2.65) and suPAR (OR=1.71; 95% CI=1.10, 2.65) compared to the referent group. Additionally, DBP<60mmHg was associated with increased adjusted risk of cardiovascular death or MI (HR=2.04; 95% CI=1.32, 3.16) and all-cause mortality (HR=2.41; 95% CI=1.69, 3.45).
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Blood Pressure/ph [Physiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Coronary Artery Disease/pp [Physiopathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Immunity, Innate/ph [Physiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Inflammation Mediators/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Receptors, Urokinase Plasminogen Activator/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Biomarkers/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Coronary Artery Disease/bl [Blood]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Diastole
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Follow-Up Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Prognosis
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Prospective Studies
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Risk Factors
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Time Factors
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Epstein, Stephen E
790 ## - Authors
All authors Alkhoder A, Epstein SE, Gafeer MM, Hayek SS, Kim JH, Ko YA, O'Neal WT, Quyyumi AA, Sandesara PB, Shaw LJ, Sperling LS, Stahl EP, Tahhan AS, Topel ML, Vaccarino V, Wilson PWF
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1016/j.ijcard.2018.09.028">https://dx.doi.org/10.1016/j.ijcard.2018.09.028</a>
Public note https://dx.doi.org/10.1016/j.ijcard.2018.09.028
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 09/28/2018   30217423 30217423 09/28/2018 09/28/2018 Journal Article

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