MARC details
000 -LEADER |
fixed length control field |
03612nam a22005777a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
180928s20192019 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0167-5273 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1016/j.ijcard.2018.09.028 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
S0167-5273(18)31876-X [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
30217423 |
245 ## - TITLE STATEMENT |
Title |
Mechanisms underlying the J-curve for diastolic blood pressure: Subclinical myocardial injury and immune activation. |
251 ## - Source |
Source |
International Journal of Cardiology. 276:255-260, 2019 Feb 01. |
252 ## - Abbreviated Source |
Abbreviated source |
Int J Cardiol. 276:255-260, 2019 Feb 01. |
253 ## - Journal Name |
Journal name |
International journal of cardiology |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2019 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2019 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
aheadofprint |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
266 ## - Date added to catalog |
Date added to catalog |
2018-09-28 |
520 ## - SUMMARY, ETC. |
Abstract |
BACKGROUND: Low diastolic blood pressure (DBP) is associated with increased risk of cardiovascular events. In patients with coronary artery disease (CAD), limitations in coronary blood flow and immune activity are implicated mechanisms, but evidence is lacking. We investigated the association between DBP, biomarkers of myocardial injury, inflammation, immune activation and incident events in patients with CAD. |
520 ## - SUMMARY, ETC. |
Abstract |
CONCLUSION: In patients with CAD, DBP<60mmHg is associated with subclinical myocardial injury, immune/inflammatory dysregulation and incident events. Aggressive BP control may be harmful in these patients, and further investigation is warranted to determine appropriate BP targets in patients with CAD. |
520 ## - SUMMARY, ETC. |
Abstract |
Copyright (c) 2018. Published by Elsevier B.V. |
520 ## - SUMMARY, ETC. |
Abstract |
METHODS: We studied 2448 adults (mean age 65+/-12years, 68% male, median follow-up 4.5years) with CAD. DBP was categorized into 10mmHg increments. Biomarkers of myocardial injury (high sensitivity cardiac troponin-I [hs-cTnI]) and immune activity/inflammation (soluble urokinase plasminogen activator receptor [suPAR]) were dichotomized at their median values. DBP 70-79mmHg was used as the referent group, and individuals were followed prospectively for adverse outcomes. |
520 ## - SUMMARY, ETC. |
Abstract |
RESULTS: After adjusting for demographic and clinical covariates, individuals with DBP<60mmHg had increased odds of elevated levels of hs-cTnI (OR=1.68; 95% CI=1.07, 2.65) and suPAR (OR=1.71; 95% CI=1.10, 2.65) compared to the referent group. Additionally, DBP<60mmHg was associated with increased adjusted risk of cardiovascular death or MI (HR=2.04; 95% CI=1.32, 3.16) and all-cause mortality (HR=2.41; 95% CI=1.69, 3.45). |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Blood Pressure/ph [Physiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Coronary Artery Disease/pp [Physiopathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Immunity, Innate/ph [Physiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Inflammation Mediators/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Receptors, Urokinase Plasminogen Activator/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Biomarkers/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Coronary Artery Disease/bl [Blood] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Diastole |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Female |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Follow-Up Studies |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Male |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Middle Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Prognosis |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Prospective Studies |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Risk Factors |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Time Factors |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Health Research Institute |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Epstein, Stephen E |
790 ## - Authors |
All authors |
Alkhoder A, Epstein SE, Gafeer MM, Hayek SS, Kim JH, Ko YA, O'Neal WT, Quyyumi AA, Sandesara PB, Shaw LJ, Sperling LS, Stahl EP, Tahhan AS, Topel ML, Vaccarino V, Wilson PWF |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1016/j.ijcard.2018.09.028">https://dx.doi.org/10.1016/j.ijcard.2018.09.028</a> |
Public note |
https://dx.doi.org/10.1016/j.ijcard.2018.09.028 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |