MARC details
| 000 -LEADER |
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| fixed length control field |
03173nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180928s20182018 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0046-8177 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1016/j.humpath.2018.08.021 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
S0046-8177(18)30337-X [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
30179687 |
| 245 ## - TITLE STATEMENT |
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| Title |
Histologic Findings Associated with False Positive Multiparametric Magnetic Resonance Imaging Performed for Prostate Cancer Detection. |
| 251 ## - Source |
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| Source |
Human Pathology. 2018 Sep 01 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Hum Pathol. 2018 Sep 01 |
| 253 ## - Journal Name |
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| Journal name |
Human pathology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2018 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2018-09-28 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Copyright (c) 2018. Published by Elsevier Inc. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Magnetic Resonance Imaging (MRI)/Ultrasound fusion-targeted biopsy (TB) has been shown to more accurately identify higher grade prostate cancers compared to standard-of-care systematic sextant prostate biopsy (SB). However, occasional false positive imaging findings occur. We investigated the histologic findings associated with false positive prostate MRI findings. A retrospective review was performed on our surgical pathology database from 2014-2017 selecting patients with no cancer detected on TB with concurrent SB following at least one prior benign SB session. Histologic features evaluated included percentage of core involvement by chronic inflammation, percentage of core composed of stroma, percentage of glands involved by atrophy, and presence of the following features: acute or granulomatous inflammation, stromal nodular hyperplasia, adenosis, squamous metaplasia, basal cell hyperplasia, presence of skeletal muscle. Histologic findings were compared between TB and concurrent SB. We identified 544 patients who underwent TB. Of these, 41 patients, including 62 targeted lesions, met criteria. Compared to SB tissue, the mean percentage of stroma was increased in TB (P=.02). Basal cell hyperplasia was also found to be more common on TB (P=.02). Both high percentage of stroma (P=.046) and presence of basal cell hyperplasia (P=.038) were independent predictors on multivariate analysis. The combination of high chronic inflammation, high stroma, acute inflammation, and basal cell hyperplasia was associated with TB (P=.001). Atrophic glands and chronic inflammation showed a positive correlation (r=0.67, P=.003), which was especially seen in high prostate imaging reporting and data system lesions. Specific benign histologic entities are associated with false positive findings on prostate MRI. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Neurology |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Ullman, Michael |
| 790 ## - Authors |
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| All authors |
Bae S, Calderone CE, Del Carmen Rodriguez Pena M, Gordetsky JB, Nix JW, Porter KK, Rais-Bahrami S, Schultz L, Ullman D, Ullman M |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1016/j.humpath.2018.08.021">https://dx.doi.org/10.1016/j.humpath.2018.08.021</a> |
| Public note |
https://dx.doi.org/10.1016/j.humpath.2018.08.021 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
