MARC details
000 -LEADER |
fixed length control field |
04044nam a22004097a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
190724s20182018 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
2168-6149 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1001/jamaneurol.2018.2338 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
2696968 [pii] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
PMC6583201 [pmc] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
30167675 |
245 ## - TITLE STATEMENT |
Title |
Effect of Dextroamphetamine on Poststroke Motor Recovery: A Randomized Clinical Trial. |
251 ## - Source |
Source |
JAMA Neurology. 75(12):1494-1501, 2018 Dec 01. |
252 ## - Abbreviated Source |
Abbreviated source |
JAMA Neurol. 75(12):1494-1501, 2018 Dec 01. |
253 ## - Journal Name |
Journal name |
JAMA neurology |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2018 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2019 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
266 ## - Date added to catalog |
Date added to catalog |
2018-09-28 |
520 ## - SUMMARY, ETC. |
Abstract |
Conclusions and Relevance: Treatment with dextroamphetamine combined with physical therapy did not improve recovery of motor function compared with placebo combined with physical therapy as assessed 3 months after hemispheric ischemic stroke. The studied treatment regimen was safe. |
520 ## - SUMMARY, ETC. |
Abstract |
Design, Setting, Participants: This pilot, double-blind, block-randomized clinical trial included patients with cortical or subcortical ischemic stroke and moderate or severe motor deficits from 5 rehabilitation hospitals or units. Participants were screened and enrolled from March 2001 through March 2003. The primary outcome was assessed 3 months after stroke. Study analysis was completed December 31, 2015. A total of 1665 potential participants were screened and 64 were randomized. Participants had to begin treatment 10 to 30 days after ischemic stroke. Data analysis was based on intention to treat. |
520 ## - SUMMARY, ETC. |
Abstract |
Importance: Data from animal models show that the administration of dextroamphetamine combined with task-relevant training facilitates recovery after focal brain injury. Results of clinical trials in patients with stroke have been inconsistent. |
520 ## - SUMMARY, ETC. |
Abstract |
Interventions: Participants were allocated to a regimen of 10 mg of dextroamphetamine (n = 32) or placebo (n = 32) combined with a 1-hour physical therapy session beginning 1 hour after drug or placebo administration every 4 days for 6 sessions in addition to standard rehabilitation. |
520 ## - SUMMARY, ETC. |
Abstract |
Main Outcomes and Measures: The primary outcome was the difference between groups in change in Fugl-Meyer motor scores from baseline to 3 months after stroke (intention to treat with dextroamphetamine). Secondary exploratory measures included the National Institutes of Health Stroke Scale, Canadian Neurological Scale, Action Research Arm Test, modified Rankin Scale score, Functional Independence Measure, Ambulation Speed and Distance, Mini-Mental State Examination, Beck Depression Inventory, and Stroke Impact Scale. |
520 ## - SUMMARY, ETC. |
Abstract |
Objectives: To collect data important for future studies evaluating the effect of dextroamphetamine combined with physiotherapy for improving poststroke motor recovery and to test the efficacy of the approach. |
520 ## - SUMMARY, ETC. |
Abstract |
Results: Among the 64 patients randomized to dextroamphetamine vs placebo (55% men; median age, 66 years; age range, 27-91 years), no overall treatment-associated difference in the mean (SEM) change in Fugl-Meyer motor scores from baseline to 3 months after stroke was noted (-18.65 [2.27] points with dextroamphetamine vs -20.83 [2.94] points with placebo; P = .58). No overall treatment-associated differences in any of the study's secondary measures and no differences in subgroups based on stroke location or baseline severity were found. No adverse events were attributed to study treatments. |
520 ## - SUMMARY, ETC. |
Abstract |
Trial Registration: ClinicalTrials.gov identifier: NCT01905371. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar National Rehabilitation Network |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Dromerick, Alexander W |
790 ## - Authors |
All authors |
Dromerick AW, Goldstein LB, Good DC, Lennihan L, Pura J, Rabadi MJ, Reding MJ, Samsa GP |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1001/jamaneurol.2018.2338">https://dx.doi.org/10.1001/jamaneurol.2018.2338</a> |
Public note |
https://dx.doi.org/10.1001/jamaneurol.2018.2338 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |