MARC details
| 000 -LEADER |
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| fixed length control field |
04804nam a22005177a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190724s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0195-668X |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1093/eurheartj/ehy653 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
5198769 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
EMS80890 [mid] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC6374687 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
30476079 |
| 245 ## - TITLE STATEMENT |
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| Title |
Equalization of four cardiovascular risk algorithms after systematic recalibration: individual-participant meta-analysis of 86 prospective studies. |
| 251 ## - Source |
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| Source |
European Heart Journal. 40(7):621-631, 2019 02 14. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Eur Heart J. 40(7):621-631, 2019 02 14. |
| 252 ## - Abbreviated Source |
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| Former abbreviated source |
Eur Heart J. 40(7):621-631, 2019 02 14. |
| 253 ## - Journal Name |
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| Journal name |
European heart journal |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2018-12-14 |
| 268 ## - Previous citation |
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| -- |
European Heart Journal. 40(7):621-631, 2019 02 14. |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1996 - present (after 1 year), Available in print through MWHC library: 1999 - 2006 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
AIMS: There is debate about the optimum algorithm for cardiovascular disease (CVD) risk estimation. We conducted head-to-head comparisons of four algorithms recommended by primary prevention guidelines, before and after 'recalibration', a method that adapts risk algorithms to take account of differences in the risk characteristics of the populations being studied. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: Before recalibration, the clinical performance of four widely used CVD risk algorithms varied substantially. By contrast, simple recalibration nearly equalized their performance and improved modelled targeting of preventive action to clinical need. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Copyright (c) The Author(s) 2018. Published by Oxford University Press on behalf of the European Society of Cardiology. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS AND RESULTS: Using individual-participant data on 360 737 participants without CVD at baseline in 86 prospective studies from 22 countries, we compared the Framingham risk score (FRS), Systematic COronary Risk Evaluation (SCORE), pooled cohort equations (PCE), and Reynolds risk score (RRS). We calculated measures of risk discrimination and calibration, and modelled clinical implications of initiating statin therapy in people judged to be at 'high' 10 year CVD risk. Original risk algorithms were recalibrated using the risk factor profile and CVD incidence of target populations. The four algorithms had similar risk discrimination. Before recalibration, FRS, SCORE, and PCE over-predicted CVD risk on average by 10%, 52%, and 41%, respectively, whereas RRS under-predicted by 10%. Original versions of algorithms classified 29-39% of individuals aged >=40 years as high risk. By contrast, recalibration reduced this proportion to 22-24% for every algorithm. We estimated that to prevent one CVD event, it would be necessary to initiate statin therapy in 44-51 such individuals using original algorithms, in contrast to 37-39 individuals with recalibrated algorithms. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Algorithms |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Cardiovascular Diseases/et [Etiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Calibration |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Female |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Male |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Middle Aged |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Prospective Studies |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Risk Assessment |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shara, Nawar M |
| 790 ## - Authors |
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| All authors |
Amouyel P, Arima H, Assmann G, Barr ELM, Barrett-Connor E, Ben-Shlomo Y, Bjorkelund C, Blaha MJ, Blazer DG, Bolton T, Brenner H, Brunner EJ, Burgess S, Casiglia E, Coady S, Cook NR, Cooper C, Cooper JA, Crespo CJ, D'Agostino RB, Daimon M, Danesh J, Dankner R, Davidson KW, Davis BR, Dekker JM, Di Angelantonio E, Donfrancesco C, Ducimetiere P, Emerging Risk Factors Collaboration, Engstrom G, Ezzati M, Ford I, Gallacher J, Gansevoort RT, Gillum RF, Goldbourt U, Gomez de la Camara A, Graham I, Greenland P, Gudnason V, Jackson R, Jorgensen T, Kaptoge S, Kauhanen J, Kavousi M, Khaw KT, Kiechl S, Kivimaki M, Knuiman MW, Koenig W, Kromhout D, Krumholz HM, Kuller LH, Lamarche B, Lawlor DA, Marin Ibanez A, Meade TW, Meisinger C, Monique Verschuren WM, Moons KGM, Nagel D, Nietert PJ, Nissinen A, Njolstad I, Nordestgaard BG, Onat A, Onuma O, Palmieri L, Pavlovic J, Pennells L, Price JF, Psaty BM, Ridker PM, Rodriguez B, Rosengren A, Roussel R, Sakurai M, Salomaa V, Sato S, Sattar N, Selmer R, Shara N, Simons LA, Sundstrom J, Sweeting M, Thompson SG, Tipping RW, Trevisan M, van der Schouw YT, Varghese CV, Visser M, Volzke H, Wallace RB, Whincup PH, White I, Willeit P, Wood A, Woodward M, Wouter Jukema J, Zhao X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1093/eurheartj/ehy653">https://dx.doi.org/10.1093/eurheartj/ehy653</a> |
| Public note |
https://dx.doi.org/10.1093/eurheartj/ehy653 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
