MARC details
| 000 -LEADER |
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| fixed length control field |
03203nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190118s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0924-8579 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1016/j.ijantimicag.2019.01.004 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
S0924-8579(19)30004-4 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
30639629 |
| 245 ## - TITLE STATEMENT |
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| Title |
Fluoroquinolone-based versus beta lactam-based regimens for complicated intra-abdominal infections: a meta-analysis of randomized controlled trials. [Review] |
| 251 ## - Source |
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| Source |
International Journal of Antimicrobial Agents. 2019 Jan 10 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Int J Antimicrob Agents. 2019 Jan 10 |
| 253 ## - Journal Name |
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| Journal name |
International journal of antimicrobial agents |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2019-01-18 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Complicated intra-abdominal infections (cIAIs) are common and confer significant morbidity, mortality, and cost. In this era of evolving antimicrobial resistance, selection of appropriate empiric antimicrobials is paramount. This systematic review and meta-analysis of randomized controlled trials compares the effectiveness and safety of fluoroquinolone (FQ) versus beta-lactam (BL)-based regimens for the treatment of patients with cIAIs. The primary outcomes were treatment success in the clinically-evaluable (CE) and all-cause mortality in the intention-to-treat (ITT) population. Subgroup analyses were performed based on specific antimicrobials, source of infection, and isolated pathogens. Seven trials (4125 patients) were included. FQ-based regimens included moxifloxacin (4 studies) or ciprofloxacin/metronidazole (3 studies); BL-based regimens were ceftriaxone/metronidazole (3 studies), carbapenems (2 studies), or piperacillin/tazobactam (2 studies). There was no difference in effectiveness in the CE [2883 patients, pooled risk ratio (RR) 1.00, 95% CI 0.95 - 1.04] or ITT population (3055 patients, RR 0.97 [0.94 - 1.01]); mortality (3614 patients, RR 1.04 [0.75 - 1.43]), and related adverse events (2801 patients, RR 0.97 [0.70 - 1.33]) were also similar. On subset analysis, moxifloxacin was slightly less effective than beta lactams in the CE (1934 patients, RR 0.96 [0.93 - 0.99]) and ITT population (1743 patients, RR 0.94 [0.91 - 0.98]). Although, fluoroquinolone-based and beta lactam-based regimens appear equally effective and safe for the treatment of patients with cIAIs, limited data suggests slightly inferior results with moxifloxacin. Selection of empiric coverage should be based on local bacterial epidemiology and patterns of resistance, as well as stewardship protocols. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Copyright (c) 2019. Published by Elsevier B.V. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Surgery/General Surgery |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Surgery/Trauma Surgery |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Review |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Mavros, Michail N |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sava, Jack |
| 790 ## - Authors |
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| All authors |
Economopoulos KP, Falagas ME, Kyriakidou M, Mavros MN, Sava JA, Theochari NA |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1016/j.ijantimicag.2019.01.004">https://dx.doi.org/10.1016/j.ijantimicag.2019.01.004</a> |
| Public note |
https://dx.doi.org/10.1016/j.ijantimicag.2019.01.004 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
