MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03171nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
220706s20222022 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
|---|
| International Standard Serial Number |
2730-664X |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
10.1038/s43856-022-00111-w [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
111 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
|---|
| Standard number or code |
PMC9135751 [pmc] |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| PMID |
35647608 |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Maternal psychological distress during the COVID-19 pandemic and structural changes of the human fetal brain. |
| 251 ## - Source |
|---|
| Source |
Communication medicale. 2:47, 2022. |
| 252 ## - Abbreviated Source |
|---|
| Abbreviated source |
Commun. med.. 2:47, 2022. |
| 253 ## - Journal Name |
|---|
| Journal name |
Communications medicine |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Year |
2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Manufacturer |
FY2022 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
|---|
| Publication status |
epublish |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
|---|
| Medline status |
PubMed-not-MEDLINE |
| 266 ## - Date added to catalog |
|---|
| Date added to catalog |
2022-07-06 |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Background: Elevated maternal psychological distress during pregnancy is linked to adverse outcomes in offspring. The potential effects of intensified levels of maternal distress during the COVID-19 pandemic on the developing fetal brain are currently unknown. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Conclusions: We report impaired fetal brain growth and delayed cerebral cortical gyrification in COVID-19 pandemic era pregnancies, in the setting of heightened maternal psychological distress. The potential long-term neurodevelopmental consequences of altered fetal brain development in COVID-era pregnancies merit further study. Copyright © The Author(s) 2022. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Methods: We prospectively enrolled 202 pregnant women: 65 without known COVID-19 exposures during the pandemic who underwent 92 fetal MRI scans, and 137 pre-pandemic controls who had 182 MRI scans. Multi-plane, multi-phase single shot fast spin echo T2-weighted images were acquired on a GE 1.5 T MRI Scanner. Volumes of six brain tissue types were calculated. Cortical folding measures, including brain surface area, local gyrification index, and sulcal depth were determined. At each MRI scan, maternal distress was assessed using validated stress, anxiety, and depression scales. Generalized estimating equations were utilized to compare maternal distress measures, brain volume and cortical folding differences between pandemic and pre-pandemic cohorts. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Results: Stress and depression scores are significantly higher in the pandemic cohort, compared to the pre-pandemic cohort. Fetal white matter, hippocampal, and cerebellar volumes are decreased in the pandemic cohort. Cortical surface area and local gyrification index are also decreased in all four lobes, while sulcal depth is lower in the frontal, parietal, and occipital lobes in the pandemic cohort, indicating delayed brain gyrification. |
| 546 ## - LANGUAGE NOTE |
|---|
| Language note |
English |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
|---|
| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
|---|
| Department |
Maternal-Fetal Medicine & Genetics Fellowship |
| 657 ## - INDEX TERM--FUNCTION |
|---|
| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Local Authors |
Saeed, Haleema |
| Institution Code |
MedStar Washington Hospital Center |
| Program |
Maternal-Fetal Medicine & Genetics Fellowship |
| 790 ## - Authors |
|---|
| All authors |
Andersen NR, Andescavage N, Barnett SD, du Plessis A, Henderson D, Kapse K, Limperopoulos C, Lopez C, Lu YC, Quistorff J, Saeed H, Vezina G, Wessel D, Wu Y |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| DOI |
<a href="https://dx.doi.org/10.1038/s43856-022-00111-w">https://dx.doi.org/10.1038/s43856-022-00111-w</a> |
| Public note |
https://dx.doi.org/10.1038/s43856-022-00111-w |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
