MARC details
| 000 -LEADER |
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| fixed length control field |
03349nam a22003137a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
190724s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0194-911X |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1161/HYPERTENSIONAHA.119.12907 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
31256717 |
| 245 ## - TITLE STATEMENT |
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| Title |
Association of Total Medication Burden With Intensive and Standard Blood Pressure Control and Clinical Outcomes: A Secondary Analysis of SPRINT. |
| 251 ## - Source |
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| Source |
Hypertension. :HYPERTENSIONAHA11912907, 2019 Jul 01 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Hypertension. :HYPERTENSIONAHA11912907, 2019 Jul 01 |
| 253 ## - Journal Name |
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| Journal name |
Hypertension (Dallas, Tex. : 1979) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2019-07-24 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1979 - present |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Total medication burden (antihypertensive and nonantihypertensive medications) may be associated with poor systolic blood pressure (SBP) control. We investigated the association of baseline medication burden and clinical outcomes and whether the effect of the SBP intervention varied according to baseline medication burden in SPRINT (Systolic Blood Pressure Intervention Trial). Participants were randomized to intensive or standard SBP goal (below 120 or 140 mm Hg, respectively); n=3769 participants with high baseline medication burden (>=5 medications) and n=5592 with low burden (<5 medications). Primary outcome: differences in SBP. Secondary outcomes: 8-item Morisky Medication Adherence Scale and modified Treatment Satisfaction Questionnaire for Medications measured at baseline and 12 months and incident cardiovascular disease events and serious adverse events throughout the trial. Participants in the intensive group with high versus low medication burden were less likely to achieve their SBP goal at 12 months (risk ratio, 0.91; 95% CI, 0.85-0.97) but not in the standard group (risk ratio, 0.98; 95% CI, 0.93-1.03; P<sub>interaction</sub><0.001). High medication burden was associated with increased cardiovascular disease events (hazard ratio, 1.39; 95% CI, 1.14-1.70) and serious adverse events (hazard ratio, 1.34; 95% CI, 1.24-1.45), but the effect of intensive versus standard treatment did not vary between medication burden groups ( P<sub>interaction</sub>>0.5). Medication burden had minimal association with adherence or satisfaction. High baseline medication burden was associated with worse intensive SBP control and higher rates of cardiovascular disease events and serious adverse events. The relative benefits and risks of intensive SBP goals were similar regardless of medication burden. Clinical Trial Registration- URL: http://www.clinicaltrials.gov . Unique identifier: NCT01206062. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Weintraub, William |
| 790 ## - Authors |
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| All authors |
Bates JT, Berlowitz DR, Bress AP, Chang TI, Chonchol M, Cushman WC, Derington CG, Foy CG, Greene TH, Gums TH, Herrick JS, Herring CT, Katz LA, King JB, Kronish IM, Krousel-Wood M, Moran AE, Morisky DE, Pajewski NM, Reynolds K, Saseen JJ, SPRINT Research Group, Tamariz L, Trinkley KE, Weintraub WS |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12907">https://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12907</a> |
| Public note |
https://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12907 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
