Testing the product of slopes in related regressions. (Record no. 4514)

000 -LEADER
fixed length control field 02186nam a22003257a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 180508s20132013 xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number 25346580
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0972-3617
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC4206214 [pmc]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code NIHMS520123 [mid]
190 ## -
-- Morrell CH
190 ## -
-- Shetty V
190 ## -
-- Phillips T
190 ## -
-- Arumugam TV
190 ## -
-- Mattson MP
190 ## -
-- Wan R
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Shetty, Veena
245 ## - TITLE STATEMENT
Title Testing the product of slopes in related regressions.
251 ## -
-- Advances & Applications in Statistics. 36(1):29-46, 2013 Sep 01
252 ## -
-- Adv. Appl. Stat.. 36(1):29-46, 2013 Sep 01
253 ## -
-- Advances and applications in statistics
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2013
269 ## -
-- FY2014
520 ## - SUMMARY, ETC.
Summary, etc. A study was conducted of the relationships among neuroprotective factors and cytokines in brain tissue of mice at different ages that were examined on the effect of dietary restriction on protection after experimentally induced brain stroke. It was of interest to assess whether the cross-product of the slopes of pairs of variables vs. age was positive or negative. To accomplish this, the product of the slopes was estimated and tested to determine if it is significantly different from zero. Since the measurements are taken on the same animals, the models used must account for the non-independence of the measurements within animals. A number of approaches are illustrated. First a multivariate multiple regression model is employed. Since we are interested in a nonlinear function of the parameters (the product) the delta method is used to obtain the standard error of the estimate of the product. Second, a linear mixed-effects model is fit that allows for the specification of an appropriate correlation structure among repeated measurements. The delta method is again used to obtain the standard error. Finally, a non-linear mixed-effects approach is taken to fit the linear-mixed-effects model and conduct the test. A simulation study investigates the properties of the procedure.
546 ## - LANGUAGE NOTE
Language note English
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name MedStar Health Research Institute
657 ## - INDEX TERM--FUNCTION
Function Journal Article
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection code Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 2018-05-08 25346580 2018-05-08 2018-05-08 Journal Article

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