MARC details
| 000 -LEADER |
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| fixed length control field |
02806nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191010s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2228-7523 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.5812/aapm.89990 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC6712359 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
31497519 |
| 245 ## - TITLE STATEMENT |
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| Title |
Efficacy of Methotrexate on Pain Severity Reduction and Improvement of Quality of Life in Patients with Moderate to Severe Knee Osteoarthritis. |
| 251 ## - Source |
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| Source |
Anesthesiology & Pain Medicine. 9(3):e89990, 2019 Jun. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Anesth. pain med.. 9(3):e89990, 2019 Jun. |
| 253 ## - Journal Name |
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| Journal name |
Anesthesiology and pain medicine |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2019 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2019-10-10 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Background: Knee osteoarthritis (OA) leads to low quality of life due to pain and limitation in daily activities. Recent studies indicated that Methotrexate (MTX) could reduce pain due to its anti-inflammatory effects. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Conclusions: Treatment of moderate to severe knee OA with MTX could reduce pain severity and improve functional status and quality of life in OA patients. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Methods: In this randomized clinical trial, 100 patients with moderate to severe knee OA were allocated to receive MTX (n = 50) 7.5 mg weekly to be increased to 15 mg weekly after first months or placebo (n = 50) for six months. Pain severity was measured using the numerical rating scale (NRS), so was functional status by Western Ontario and McMaster Universities Arthritis Index (WOMAC) and quality of life by SF-12 questionnaire before the treatment, and three months and six months after the intervention. The results were compared between the groups subsequently. Nine patients from the MTX group were excluded due to the use of corticosteroids during the treatment period. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Objectives: In this study, the researchers aimed at evaluating the efficacy of MTX in pain control and improvement of quality of life in patients with moderate to severe knee OA. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Results: The MTX group compared to the placebo group had significant improvement in pain severity and quality of life during six months and WOMAC parameters at three and six months after the intervention. The need for NSAIDS was slightly higher in the placebo group with no significant difference (22% versus 36%, P = 0.14). The MTX adverse effects were not observed. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/Internal Medicine |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Hemmati, Mehdi |
| 790 ## - Authors |
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| All authors |
Enteshari-Moghaddam A, Habibzadeh A, Hemmati M, Isazadehfar K |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.5812/aapm.89990">https://dx.doi.org/10.5812/aapm.89990</a> |
| Public note |
https://dx.doi.org/10.5812/aapm.89990 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
