MARC details
| 000 -LEADER |
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| fixed length control field |
03124nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191204s20192019 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1079-5006 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1093/gerona/glz045 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
5315587 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
30753301 |
| 245 ## - TITLE STATEMENT |
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| Title |
Association Between Antipsychotics and All-Cause Mortality Among Community-Dwelling Older Adults. |
| 251 ## - Source |
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| Source |
Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 74(12):1916-1921, 2019 Nov 13. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
J Gerontol A Biol Sci Med Sci. 74(12):1916-1921, 2019 Nov 13. |
| 253 ## - Journal Name |
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| Journal name |
The journals of gerontology. Series A, Biological sciences and medical sciences |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2019 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2019-12-04 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: Antipsychotics are prescribed to treat various symptoms in older adults, however, their safety in this context has not been fully evaluated. The objective was to evaluate mortality risks associated with off-label use of antipsychotics among older adults with no preexisting mental illness or dementia relative to those with diagnosis of dementia. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: In a large cohort of older adults, antipsychotics were associated with an increased risk of all-cause mortality. While significant increase in mortality was attributable to the diagnosis of dementia, the addition of antipsychotics resulted in added mortality risk among all patients. Antipsychotic medications should be used cautiously in all older adults, not only those with dementia. Copyright Published by Oxford University Press on behalf of The Gerontological Society of America 2019. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: Data (2007-2015) were derived from Department of Veterans Affairs registries for 730,226 patients (>=65 years) with no baseline serious mental illness, dementia). We estimated the cumulative incidence of antipsychotics prescription and 10-year all-cause mortality. The extended Cox models were used to estimate Hazard Ratios (HRs) associated with antipsychotics prescription, adjusted for time-varying covariates, dementia diagnosis, comorbidity index score, and age at time of first exposure to antipsychotics. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: The study included 98% males, 13% African Americans, and 81% Caucasian. Patients with dementia and antipsychotics had the highest risk of mortality (78.0%), followed by (73.0%) for patients with dementia alone and compared with patients without dementia or antipsychotics exposure who had the lowest mortality risk (42.0%). Exposure to typical antipsychotics was associated with (HR: 2.1, confidence interval [CI] 2.0-2.2) compared with atypical antipsychotics (HR: 1.5, CI 1.4-1.5, p = <.0001). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shara, Nawar M |
| 790 ## - Authors |
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| All authors |
Balish M, Boustani MA, Fokar A, Kheirbek RE, Little JT, Llorente M, Shara NM |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1093/gerona/glz045">https://dx.doi.org/10.1093/gerona/glz045</a> |
| Public note |
https://dx.doi.org/10.1093/gerona/glz045 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
