Cognitive Correlates of MRI-defined Cerebral Vascular Injury and Atrophy in Elderly American Indians: The Strong Heart Study. (Record no. 4803)

MARC details
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fixed length control field 03303nam a22003497a 4500
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fixed length control field 191219s20192019 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1355-6177
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1017/S1355617719001073 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S1355617719001073 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 31791442
245 ## - TITLE STATEMENT
Title Cognitive Correlates of MRI-defined Cerebral Vascular Injury and Atrophy in Elderly American Indians: The Strong Heart Study.
251 ## - Source
Source Journal of the International Neuropsychological Society. :1-13, 2019 Dec 03
252 ## - Abbreviated Source
Abbreviated source J Int Neuropsychol Soc. :1-13, 2019 Dec 03
253 ## - Journal Name
Journal name Journal of the International Neuropsychological Society : JINS
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2019
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2020
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status aheadofprint
266 ## - Date added to catalog
Date added to catalog 2019-12-17
520 ## - SUMMARY, ETC.
Abstract CONCLUSIONS: Brain-cognition associations found in this study of elderly American Indians are similar to those found in other racial/ethnic populations, with processing speed comprising an especially strong correlate of cerebrovascular disease. These findings may assist future efforts to define opportunities for disease prevention, to conduct research on diagnostic and normative standards, and to guide clinical evaluation of this underserved and overburdened population.
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Abstract METHODS: We examined 786 American Indians aged 64 years and older from the Cerebrovascular Disease and its Consequences in American Indians study (2010-2013). Cranial magnetic resonance images were scored for cortical and subcortical infarcts, hemorrhages, severity of white matter disease, sulcal widening, ventricle enlargement, and volumetric estimates for white matter hyperintensities (WMHs), hippocampus, and brain. Participants completed demographic, medical history, and neuropsychological assessments including testing for general cognitive functioning, verbal learning and memory, processing speed, phonemic fluency, and executive function.
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Abstract OBJECTIVE: American Indians experience substantial health disparities relative to the US population, including vascular brain aging. Poorer cognitive test performance has been associated with cranial magnetic resonance imaging findings in aging community populations, but no study has investigated these associations in elderly American Indians.
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Abstract RESULTS: Processing speed was independently associated with the presence of any infarcts, white matter disease, and hippocampal and brain volumes, independent of socioeconomic, language, education, and clinical factors. Other significant associations included general cognitive functioning with hippocampal volume. Nonsignificant, marginal associations included general cognition with WMH and brain volume; verbal memory with hippocampal volume; verbal fluency and executive function with brain volume; and processing speed with ventricle enlargement.
546 ## - LANGUAGE NOTE
Language note English
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Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Health Research Institute, Phoenix, AZ
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Medline publication type Journal Article
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Local Authors Calhoun, Darren
790 ## - Authors
All authors Ali T, Buchwald D, Calhoun D, Cholerton B, Longstreth WT, Montine TJ, Nelson L, Shibata D, Suchy-Dicey A, Verney SP
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1017/S1355617719001073">https://dx.doi.org/10.1017/S1355617719001073</a>
Public note https://dx.doi.org/10.1017/S1355617719001073
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
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          MedStar Authors Catalog MedStar Authors Catalog 12/17/2019   31791442 31791442 12/17/2019 12/17/2019 Journal Article

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