MARC details
| 000 -LEADER |
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| fixed length control field |
03739nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
200709s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0028-4793 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1056/NEJMoa1916370 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
32227753 |
| 245 ## - TITLE STATEMENT |
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| Title |
Health-Status Outcomes with Invasive or Conservative Care in Coronary Disease. |
| 251 ## - Source |
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| Source |
New England Journal of Medicine. 2020 Mar 30 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
N Engl J Med. 2020 Mar 30 |
| 253 ## - Journal Name |
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| Journal name |
The New England journal of medicine |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2020 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-07-09 |
| 501 ## - WITH NOTE |
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| Local holdings |
Available online from MWHC library: 1993 - present, Available in print through MWHC library: 1980 - present |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.). Copyright (c) 2020 Massachusetts Medical Society. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
METHODS: We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
RESULTS: At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Weintraub, William S |
| 790 ## - Authors |
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| All authors |
Alexander KP, Baloch K, Bangalore S, Boden WE, Cohen DJ, Diaz A, Gosselin G, Harrell FE Jr, Hochman JS, ISCHEMIA Research Group, Jones PG, Mark DB, Maron DJ, Mavromatis K, Mavromichalis S, Newman JD, O'Brien SM, Reynolds HR, Rosenberg Y, Spertus JA, Stone GW, Weintraub WS |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1056/NEJMoa1916370">https://dx.doi.org/10.1056/NEJMoa1916370</a> |
| Public note |
https://dx.doi.org/10.1056/NEJMoa1916370 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
