MARC details
| 000 -LEADER |
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| fixed length control field |
03674nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
200902s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1941-7640 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1161/CIRCINTERVENTIONS.119.008792 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
32674676 |
| 245 ## - TITLE STATEMENT |
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| Title |
Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement: An Analysis of the PARTNER 2 Trial and Registry. |
| 251 ## - Source |
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| Source |
Circulation: Cardiovascular Interventions. 13(7):e008792, 2020 Jul. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Circ., Cardiovasc. interv.. 13(7):e008792, 2020 Jul. |
| 253 ## - Journal Name |
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| Journal name |
Circulation. Cardiovascular interventions |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-09-02 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: Although aortic valve replacement is associated with a major benefit in high-gradient (HG) severe aortic stenosis (AS), the results in low-gradient (LG, mean gradient <40 mm Hg) AS are conflicting. LG severe AS may be subdivided in classical low-flow (left ventricular ejection fraction <50%) and LG (CLF-LG); paradoxical low-flow (left ventricular ejection fraction >=50% but stroke volume index <35 mL/m2) and LG; and normal-flow (left ventricular ejection fraction >=50% and stroke volume index >=35 mL/m2) and LG. The primary objective is to determine in the PARTNER 2 trial (The Placement of Aortic Transcatheter Valves) and registry the outcomes after aortic valve replacement of the 4 flow-gradient groups. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSIONS: The LG AS pattern was highly prevalent (36.5%) in the PARTNER 2 trial and registry. CLF-LG was the most common pattern of LG AS and was associated with higher rates of death, rehospitalization, or stroke at 2 years compared with the HG group. Clinical outcomes were as good in the LG AS groups with preserved left ventricular ejection fraction compared with the HG group. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: A total of 3511 patients from the PARTNER 2 Cohort A randomized trial (n=1910) and SAPIEN 3 registry (n=1601) were included. The flow-gradient pattern was determined at baseline transthoracic echocardiography and classified as follows: (1) HG; (2) CLF-LG; (3) paradoxical low-flow-LG; and (4) normal-flow-LG. The primary end point for this analysis was the composite of (1) death; (2) rehospitalization for heart failure symptoms and valve prosthesis complication; or (3) stroke. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: The distribution was HG, 2229 patients (63.5%); CLF-LG, 689 patients (19.6%); paradoxical low-flow-LG, 247 patients (7.0%); and normal-flow-LG, 346 patients (9.9%). The 2-year rate of primary end point was higher in CLF-LG (38.8%) versus HG: 31.8% (P=0.002) and normal-flow-LG: 32.1% (P=0.05) but was not statistically different from paradoxical low-flow-LG: 33.6% (P=0.18). There was no significant difference in the 2-year rates of clinical events between transcatheter aortic valve replacement versus surgical aortic valve replacement in the whole cohort and within each flow-gradient group. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Asch, Federico M |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Weissman, Neil J |
| 790 ## - Authors |
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| All authors |
Alu MC, Annabi MS, Asch FM, Beaudoin J, Bernier M, Blanke P, Clavel MA, Dahou A, Douglas PS, Gertz ZM, Hahn RT, Herrmann HC, Jaber WA, Leipsic J, Leon MB, Lindman BR, Makkar R, Miller DC, Ong G, Pibarot P, Ridard C, Rodes-Cabau J, Rodriguez L, Salaun E, Thourani VH, Toubal O, Webb JG, Weissman NJ, Zhang Y |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008792">https://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008792</a> |
| Public note |
https://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.008792 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
