MARC details
| 000 -LEADER |
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| fixed length control field |
03044nam a22003617a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201006s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2210-2612 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1016/j.ijscr.2020.09.017 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
S2210-2612(20)30689-1 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
32979826 |
| 245 ## - TITLE STATEMENT |
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| Title |
Perioperative FOLFOX in management of peritoneal metastases of colorectal cancer. Case report of 2 patients. |
| 251 ## - Source |
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| Source |
International Journal of Surgery Case Reports. 75:279-285, 2020 Sep 10. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Int J Surg Case Rep. 75:279-285, 2020 Sep 10. |
| 253 ## - Journal Name |
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| Journal name |
International journal of surgery case reports |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-10-06 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: This perioperative FOLFOX treatment was completed in 2 patients and the clinical effectiveness as a result of this in-depth case reports was presented. Formal phase II studies, as a result of these pharmacokinetic and clinical investigations, have been initiated. Copyright (c) 2020 The Authors. Published by Elsevier Ltd.. All rights reserved. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
DISCUSSION: The compatibility of 5-fluorouracil and oxaliplatin was documented showing no degradation of either drug when they were mixed in-vitro over 24 h. The pharmacokinetic analysis of hyperthermic intraperitoneal chemotherapy (HIPEC) with oxaliplatin showed cytotoxic concentrations for 120 min. In order to maximize oxaliplatin's effect, both intravenous bolus and continuous infusion 5-fluorouracil was combined with early postoperative intraperitoneal chemotherapy (EPIC). In total, 200 mg/m2 of oxaliplatin was combined with a minimum of 1600 mg of 5-fluorouracil over the 24 -h treatment plan. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
INTRODUCTION: Colorectal cancer can disseminate malignant cells to the peritoneal surfaces which over time progress to peritoneal metastases. Management of this type of metastatic disease has been approached using a combined treatment that consists of cytoreductive surgery and perioperative chemotherapy. To optimize these treatments a more effective chemotherapy that is used as planned part of the surgical procedure is required. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
PRESENTATION OF CASES: Pharmacologic studies to initiate a new perioperative chemotherapy treatment were modeled after the successful systemic treatments of metastatic colorectal cancer referred to as FOLFOX. A management plan that included all of the essential features of successful systemic chemotherapy was formulated. Pharmacokinetic studies of 5-fluorouracil given both intravenously and intraperitoneally and oxaliplatin given intraperitoneally were investigated. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
Washington Cancer Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Case Reports |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Stuart, O Anthony |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sugarbaker, Paul H |
| 790 ## - Authors |
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| All authors |
Stuart OA, Sugarbaker PH |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1016/j.ijscr.2020.09.017">https://dx.doi.org/10.1016/j.ijscr.2020.09.017</a> |
| Public note |
https://dx.doi.org/10.1016/j.ijscr.2020.09.017 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
