A Prospective Study of Early Radiation Associated Cardiac Toxicity Following Neoadjuvant Chemoradiation for Distal Esophageal Cancer. (Record no. 5638)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03326nam a22003257a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201006s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2234-943X |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.3389/fonc.2020.01169 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | PMC7438722 [pmc] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 32903617 |
| 245 ## - TITLE STATEMENT | |
| Title | A Prospective Study of Early Radiation Associated Cardiac Toxicity Following Neoadjuvant Chemoradiation for Distal Esophageal Cancer. |
| 251 ## - Source | |
| Source | Frontiers in Oncology. 10:1169, 2020. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Front. oncol.. 10:1169, 2020. |
| 253 ## - Journal Name | |
| Journal name | Frontiers in oncology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | epublish |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2020-10-06 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | Purpose: This study aimed to prospectively evaluate the early effects of radiation on cardiac structure and function following neoadjuvant chemoradiation for distal esophageal cancer. Methods and Materials: Patients with non-metastatic esophageal cancer who were suitable for tri-modality therapy with concurrent chemoradiotherapy followed by esophagectomy were enrolled. Cardiac magnetic resonance imaging (CMR) was obtained at baseline and 3-5 months following completion of chemoradiation. Standardized myocardial segmentation was used to identify regions on post-treatment CMR with new T2 signal or late gadolinium enhancement (LGE). Pre and post-treatment cardiac function was assessed with quantitative end points including left ventricle end-systolic volume (LSESV). Serum biomarkers of cardiac damage including troponin I, CRP, and BNP were collected at baseline and time of follow-up CMR. Results: A total of 11 patients were enrolled from 2016 to 2018. Patients had clinical stage T2 (18%) and T3 (82%) disease with clinical N0 (27%) and N1 (73%) nodal stage. All patients completed baseline CMR and completed chemoradiotherapy. One patient did not complete follow-up CMR or serum biomarkers and was excluded from the analysis. The median time from completion of chemoradiation to follow-up CMR was 3.9 months. Three out of 10 patients (30%) developed new structural findings of myocardial fibrosis and/or reversible ischemia involving the basal and mid-inferior and inferoseptal walls. In these three patients, the LVESV was significantly increased from baseline following radiation. There were no differences in other quantitative end points or serum biomarkers between the patients with myocardial damage and those without. Conclusions: Our study is the first to our knowledge to prospectively demonstrate radiation associated structural and functional heart damage as early as 3 months following neoadjuvant chemoradiation for distal esophageal cancer. Given the early onset of this subclinical heart damage, strategies should be developed to identify patients at risk for future clinically significant heart toxicity. Copyright (c) 2020 Burke, Yeh, Kim, Bergquist, Krishnan, Barac, Srichai and Unger. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Heart & Vascular Institute |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Barac, Ana |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Srichai, Monvadi B |
| 790 ## - Authors | |
| All authors | Barac A, Bergquist P, Burke AM, Kim S, Krishnan P, Srichai MB, Unger K, Yeh C |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.3389/fonc.2020.01169">https://dx.doi.org/10.3389/fonc.2020.01169</a> |
| Public note | https://dx.doi.org/10.3389/fonc.2020.01169 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 10/06/2020 | 32903617 | 32903617 | 10/06/2020 | 10/06/2020 | Journal Article |