Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival. (Record no. 5819)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02849nam a22003497a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201229s20122012 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 1687-6121 |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 22899903 |
| 245 ## - TITLE STATEMENT | |
| Title | Systemic Chemotherapy prior to Cytoreductive Surgery and HIPEC for Carcinomatosis from Appendix Cancer: Impact on Perioperative Outcomes and Short-Term Survival. |
| 251 ## - Source | |
| Source | Gastroenterology research & practice. 2012:163284, 2012. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Gastroenterol Res Pract. 2012:163284, 2012. |
| 253 ## - Journal Name | |
| Journal name | Gastroenterology research and practice |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2012 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2012 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | ppublish |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2020-12-29 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | Background and Objectives . Systemic chemotherapy administered prior to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal mucinous adenocarcinoma of appendiceal origin (PMCA) is associated with a significant rate of histological response. The impact of preoperative systemic chemotherapy (PSC) on intraperitoneal tumor burden, completeness of cytoreduction, and perioperative complications is unknown. Methods. We analyzed prospectively collected data from our HIPEC database. Thirty-four patients with PMCA were prospectively recruited and treated with PSC. Perioperative variables and survival in this group of patients were compared against 24 patients with PMCA who did not receive PSC. Results . Ten of 34 patients (29%) receiving PSC had a complete or near complete histological response. Patients receiving PSC had a lower peritoneal carcinomatosis index, required fewer peritonectomies and visceral resections, and achieved complete cytoreduction more frequently compared to patients with no preoperative chemotherapy. The incidence of perioperative complications and survival were not significantly different between the two groups. However, patients with complete histological response had better overall survival compared to patients without complete response. Conclusions . Preoperative systemic chemotherapy in appendix-originated PMCA is associated with a significant rate of histological response which may reduce the tumor burden, facilitate less aggressive and more complete CRS, and improve short-term survival in patients with a significant histological response. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Washington Hospital Center |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | Washington Cancer Institute |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Surgery/Colorectal Surgery |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Bijelic, Lana |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Kumar, Anjali S |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Stuart, O Anthony |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Sugarbaker, Paul H |
| 790 ## - Authors | |
| All authors | Bijelic L, Kumar AS, Stuart OA, Sugarbaker PH |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.1155/2012/163284">https://dx.doi.org/10.1155/2012/163284</a> |
| Public note | https://dx.doi.org/10.1155/2012/163284 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 12/29/2020 | 22899903 | 22899903 | 12/29/2020 | 12/29/2020 | Journal Article |