MARC details
000 -LEADER |
fixed length control field |
04150nam a22005177a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
201229s20202020 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
0270-6474 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1523/JNEUROSCI.1181-20.2020 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
JNEUROSCI.1181-20.2020 [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
33097635 |
245 ## - TITLE STATEMENT |
Title |
The Pathophysiology of Dystonic Tremors and Comparison With Essential Tremor. |
251 ## - Source |
Source |
Journal of Neuroscience. 40(48):9317-9326, 2020 11 25. |
252 ## - Abbreviated Source |
Abbreviated source |
J Neurosci. 40(48):9317-9326, 2020 11 25. |
252 ## - Abbreviated Source |
Former abbreviated source |
J Neurosci. 2020 Oct 22 |
253 ## - Journal Name |
Journal name |
The Journal of neuroscience : the official journal of the Society for Neuroscience |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2020 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2021 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
aheadofprint |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
ppublish |
266 ## - Date added to catalog |
Date added to catalog |
2020-12-29 |
268 ## - Previous citation |
-- |
Journal of Neuroscience. 2020 Oct 22 |
501 ## - WITH NOTE |
Local holdings |
Available online from MWHC library: 1981 - present (after 18 months) |
520 ## - SUMMARY, ETC. |
Abstract |
There are two types of dystonic tremor syndromes (DTS), dystonic tremor (DT) and tremor associated with dystonia (TAWD), and neither is understood. DTS likely share some mechanisms with non-tremulous dystonia, and there may also be overlaps with essential tremor. We studied 21 ET (8 females, 13 males) and 22 DTS human patients (10 females, 12 males), including 13 human patients with DT (DT; writer's cramp with writing tremor) and 9 human patients with tremor associated with dystonia (TAWD; cervical dystonia with hand tremor). Tremors were analyzed using accelerometry and surface EMG of the antagonist pairs of arm muscles during posture, simple kinetic movement, and writing. Cerebellar inhibition (CBI) was performed to assess cerebello-thalamo-cortical (CTC) involvement. DT exhibited higher variability of peak frequency and greater instability of tremor burst intervals over time (higher tremor stability index; TSI) than ET or TAWD regardless of tasks. Intermuscular coherence magnitude between the antagonist pairs increased during the writing task in DT, but not ET or TAWD. ET and TAWD exhibited different phase relationships of the temporal fluctuations of voluntary movement and tremor in the kinetic condition. A linear discriminant classifier based on these tremor parameters was able to distinguish the three groups with a classification accuracy of 95.1%. CBI was significantly reduced in DT, but not in TAWD, compared to ET and healthy controls. Our study shows that the two DTS are distinct entities with DT closer to non-tremorous dystonia and TAWD closer to ET. SIGNIFICANCE STATEMENTThis study provides novel findings about characteristics and pathophysiology of the two different types of dystonic tremor syndromes (DTS), in comparison with essential tremor. Patients with DT are classified into DT (DT) who have dystonia and tremor in the same area, and tremor associated with dystonia (TAWD) who have dystonia and tremor elsewhere. Our results showed that DT exhibits increased tremor variability, instability, and intermuscular coherence, and decreased cerebello-thalamo-cortical inhibition compared to TAWD. Our study shows that DT and TAWD are distinct phenotypes, and that the physiological characteristics of DT are more similar to non-tremorous dystonia, and TAWD is closer to ET. Copyright (c) 2020 the authors. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Dystonia/pp [Physiopathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Essential Tremor/pp [Physiopathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
*Tremor/pp [Physiopathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Accelerometry |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Cerebellum/pp [Physiopathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Dystonic Disorders/pp [Physiopathology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Electromyography |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Female |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Humans |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Male |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Middle Aged |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Movement/ph [Physiology] |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
Transcranial Magnetic Stimulation |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar National Rehabilitation Network |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Journal Article |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Lee, Sang Wook |
790 ## - Authors |
All authors |
Cho HJ, Hallett M, Lee SW, Panyakaew P, Wu T |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1523/JNEUROSCI.1181-20.2020">https://dx.doi.org/10.1523/JNEUROSCI.1181-20.2020</a> |
Public note |
https://dx.doi.org/10.1523/JNEUROSCI.1181-20.2020 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |