The Pathophysiology of Dystonic Tremors and Comparison With Essential Tremor. (Record no. 5866)

MARC details
000 -LEADER
fixed length control field 04150nam a22005177a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201229s20202020 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0270-6474
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1523/JNEUROSCI.1181-20.2020 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code JNEUROSCI.1181-20.2020 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 33097635
245 ## - TITLE STATEMENT
Title The Pathophysiology of Dystonic Tremors and Comparison With Essential Tremor.
251 ## - Source
Source Journal of Neuroscience. 40(48):9317-9326, 2020 11 25.
252 ## - Abbreviated Source
Abbreviated source J Neurosci. 40(48):9317-9326, 2020 11 25.
252 ## - Abbreviated Source
Former abbreviated source J Neurosci. 2020 Oct 22
253 ## - Journal Name
Journal name The Journal of neuroscience : the official journal of the Society for Neuroscience
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2020
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2021
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status aheadofprint
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
266 ## - Date added to catalog
Date added to catalog 2020-12-29
268 ## - Previous citation
-- Journal of Neuroscience. 2020 Oct 22
501 ## - WITH NOTE
Local holdings Available online from MWHC library: 1981 - present (after 18 months)
520 ## - SUMMARY, ETC.
Abstract There are two types of dystonic tremor syndromes (DTS), dystonic tremor (DT) and tremor associated with dystonia (TAWD), and neither is understood. DTS likely share some mechanisms with non-tremulous dystonia, and there may also be overlaps with essential tremor. We studied 21 ET (8 females, 13 males) and 22 DTS human patients (10 females, 12 males), including 13 human patients with DT (DT; writer's cramp with writing tremor) and 9 human patients with tremor associated with dystonia (TAWD; cervical dystonia with hand tremor). Tremors were analyzed using accelerometry and surface EMG of the antagonist pairs of arm muscles during posture, simple kinetic movement, and writing. Cerebellar inhibition (CBI) was performed to assess cerebello-thalamo-cortical (CTC) involvement. DT exhibited higher variability of peak frequency and greater instability of tremor burst intervals over time (higher tremor stability index; TSI) than ET or TAWD regardless of tasks. Intermuscular coherence magnitude between the antagonist pairs increased during the writing task in DT, but not ET or TAWD. ET and TAWD exhibited different phase relationships of the temporal fluctuations of voluntary movement and tremor in the kinetic condition. A linear discriminant classifier based on these tremor parameters was able to distinguish the three groups with a classification accuracy of 95.1%. CBI was significantly reduced in DT, but not in TAWD, compared to ET and healthy controls. Our study shows that the two DTS are distinct entities with DT closer to non-tremorous dystonia and TAWD closer to ET. SIGNIFICANCE STATEMENTThis study provides novel findings about characteristics and pathophysiology of the two different types of dystonic tremor syndromes (DTS), in comparison with essential tremor. Patients with DT are classified into DT (DT) who have dystonia and tremor in the same area, and tremor associated with dystonia (TAWD) who have dystonia and tremor elsewhere. Our results showed that DT exhibits increased tremor variability, instability, and intermuscular coherence, and decreased cerebello-thalamo-cortical inhibition compared to TAWD. Our study shows that DT and TAWD are distinct phenotypes, and that the physiological characteristics of DT are more similar to non-tremorous dystonia, and TAWD is closer to ET. Copyright (c) 2020 the authors.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Dystonia/pp [Physiopathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Essential Tremor/pp [Physiopathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Tremor/pp [Physiopathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Accelerometry
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Cerebellum/pp [Physiopathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Dystonic Disorders/pp [Physiopathology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Electromyography
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Female
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Male
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Middle Aged
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Movement/ph [Physiology]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Transcranial Magnetic Stimulation
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar National Rehabilitation Network
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Lee, Sang Wook
790 ## - Authors
All authors Cho HJ, Hallett M, Lee SW, Panyakaew P, Wu T
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1523/JNEUROSCI.1181-20.2020">https://dx.doi.org/10.1523/JNEUROSCI.1181-20.2020</a>
Public note https://dx.doi.org/10.1523/JNEUROSCI.1181-20.2020
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 12/29/2020   33097635 33097635 12/29/2020 12/29/2020 Journal Article

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