MARC details
| 000 -LEADER |
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| fixed length control field |
03241nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
201229s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2515-5091 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1093/jncics/pkaa024 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
pkaa024 [pii] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
PMC7590517 [pmc] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
33134818 |
| 245 ## - TITLE STATEMENT |
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| Title |
Body Mass Index and Weight Loss in Metastatic Colorectal Cancer in CALGB (Alliance)/SWOG 80405. |
| 251 ## - Source |
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| Source |
JNCI Cancer Spectrum. 4(3):pkaa024, 2020 Jun. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
JNCI cancer spectr.. 4(3):pkaa024, 2020 Jun. |
| 253 ## - Journal Name |
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| Journal name |
JNCI cancer spectrum |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2020-12-29 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Background: In nonmetastatic colorectal cancer, overweight and mild-to-moderately obese patients experience improved outcomes compared with other patients. Obesity's influence on advanced or metastatic colorectal cancer (mCRC) is relatively unexplored. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Conclusions: In this prospective study of patients with mCRC, BMI at time of first-line chemotherapy initiation was not associated with patient outcome. Weight loss prior to study entry was associated with increased risk of patient mortality and disease progression. Copyright (c) The Author(s) 2020. Published by Oxford University Press. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Methods: We conducted a prospective body mass index (BMI) companion study in Cancer and Leukemia Group B (now Alliance)/SWOG 80405, a phase III metastatic colorectal cancer (mCRC) treatment trial. BMI was measured at trial registration. Primary and secondary endpoints were overall and progression-free survival, respectively. To minimize confounding by poor and rapidly declining health, we used Cox proportional hazards regression to adjust for known prognostic factors, comorbidities, physical activity, and weight loss during the 6 months prior to study entry. We also examined weight loss prior to enrollment as an independent predictor of patient outcome. All statistical tests were two-sided. |
| 520 ## - SUMMARY, ETC. |
|---|
| Abstract |
Results: Among 2323 patients with mCRC, there were no statistically significant associations between BMI and overall or progression-free survival (adjusted P trend = .12 and .40, respectively). Weight loss during the 6 months prior to study entry was associated with shorter overall and progression-free survival; compared with individuals with stable weight +/-4.9%, individuals with weight loss greater than 15% experienced an adjusted hazard ratio of 1.52 for all-cause mortality (95% confidence interval [CI] = 1.26 to 1.84; P trend < .001) and of 1.23 for disease progression or death (95% CI = 1.02 to 1.47; P trend = .006). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Hematology/Oncology |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Shaw, James E |
| 790 ## - Authors |
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| All authors |
Atkins JN, Blanke CD, Brown JC, Fuchs CS, Goldberg RM, Guercio BJ, Hochster HS, Innocenti F, Lenz HJ, Mayer RJ, Meyerhardt JA, Mullen BC, Niedzwiecki D, O'Neil BH, O'Reilly EM, Ou FS, Polite BN, Shaw JE, Venook AP, Zhang S |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1093/jncics/pkaa024">https://dx.doi.org/10.1093/jncics/pkaa024</a> |
| Public note |
https://dx.doi.org/10.1093/jncics/pkaa024 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
