Standardized Platelet Rich Plasma Injections for Osteoarthritis of the Knee. (Record no. 5915)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02753nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 201229s20202020 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2168-8184 |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.7759/cureus.10900 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | PMC7550245 [pmc] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 33062459 |
| 245 ## - TITLE STATEMENT | |
| Title | Standardized Platelet Rich Plasma Injections for Osteoarthritis of the Knee. |
| 251 ## - Source | |
| Source | Cureus. 12(10):e10900, 2020 Oct 11. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Cureus. 12(10):e10900, 2020 Oct 11. |
| 253 ## - Journal Name | |
| Journal name | Cureus |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2020 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | epublish |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2020-12-29 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | Objective Platelet-rich plasma (PRP) and adipose-derived stem cells (ADSC) injections are non-surgical treatments for knee osteoarthritis (OA). The purpose of this study is to assess the effectiveness of serial PRP with or without ADSC injections in the treatment of refractory OA of the knee. Design Patients who failed to achieve pain relief with conventional non-surgical treatments, with Kellgren-Lawrence grade 3 or 4 knee OA, were recruited from a private outpatient clinic. Over 67 patients were elected to receive serial PRP injections and 22 patients were elected to receive an ADSC+PRP injection. These patients completed Western Ontario and McMaster Universities Arthritis Index (WOMAC) surveys prior to each treatment and at follow-up appointments. These surveys were retrospectively reviewed to assess changes in functional status and pain over time. Results Twenty-nine patients from the PRP group and eight patients in the ADSC+PRP group had adequate follow-up for inclusion in the analysis. The PRP group had an improvement in WOMAC scores by 34.30%, 60.2%, and 58.5% for patients reporting at 1-3, 4-6, and >6 months of follow-up. The ADSC+PRP group experienced an improvement of 51% at an average of 4.66 months of follow-up. Conclusions Serial PRP injections and a single ADSC+PRP injection yield improved and sustained functional outcome scores for patients with severe, refractory OA of the knee. Future studies should consider consistent orthobiologic preparation protocols to ensure reproducibility. Copyright (c) 2020, Ehlers et al. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Union Memorial Hospital |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Medicine/Rheumatology |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Orthopaedics |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Marano, Geoffrey |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | McCormick, Brian P |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Schainker, Lawrence |
| 790 ## - Authors | |
| All authors | Ehlers CB, Marano G, McCormick BP, Povey K, Sarna N, Schainker L, Webb AR, Wyand TJ |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.7759/cureus.10900">https://dx.doi.org/10.7759/cureus.10900</a> |
| Public note | https://dx.doi.org/10.7759/cureus.10900 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12/29/2020 | 33062459 | 33062459 | 12/29/2020 | 12/29/2020 | Journal Article |