Inadvertent intrathecal administration of daunomycin resulting in fatality: Case report and therapeutic considerations. (Record no. 5964)

MARC details
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fixed length control field 03006nam a22003617a 4500
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fixed length control field 201231s20212021 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 2405-6502
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.ensci.2020.100297 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code PMC7750546 [pmc]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S2405-6502(20)30076-9 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 33364452
245 ## - TITLE STATEMENT
Title Inadvertent intrathecal administration of daunomycin resulting in fatality: Case report and therapeutic considerations.
251 ## - Source
Source eNeurologicalSci. 22:100297, 2021 Mar.
252 ## - Abbreviated Source
Abbreviated source eNeurologicalSci. 22:100297, 2021 Mar.
253 ## - Journal Name
Journal name eNeurologicalSci
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2021
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2021
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status epublish
266 ## - Date added to catalog
Date added to catalog 2020-12-31
520 ## - SUMMARY, ETC.
Abstract Background: Daunomycin is a chemotherapeutic agent of the anthracycline family that is administered intravenously, most commonly in combination therapy. The authors report the first known adult case of inadvertently administered daunomycin directly into the human central nervous system and the neurologic manifestations and therapeutic interventions that followed.
520 ## - SUMMARY, ETC.
Abstract Clinical description: A 53-year-old male presenting to the hospital for his second cycle of consolidation therapy for acute promyelocytic leukemia t(15;17) was accidentally administered 93 mg of intrathecal (IT) daunomycin. Within several hours of injection, the patient subsequently developed bilateral lower extremity pain, ascending paresthesias, headache, and left cranial nerve (CN) III palsy. Immediately following these neurologic sequalae, a subarachnoid lumbar drain was placed at the L4-5 interspace for the initial irrigation and drainage of cerebrospinal fluid (CSF). By hospital day 2, the patient's mental status significantly declined requiring an external ventricular drain (EVD) for hydrocephalus. Despite therapeutic interventions, the patient developed an ascending radiculomyeloencephalopathy with deterioration in clinical status. Eighteen days after the inadvertent injection of IT daunomycin, the patient became comatose and lost all cranial nerve function.
520 ## - SUMMARY, ETC.
Abstract Conclusions: Accidental IT injection of daunomycin is a neurosurgical emergency and warrants prompt intervention. Symptoms can mimic other medical conditions, making it imperative an accurate diagnosis is made so that appropriate therapies are implemented. At this time, therapies include rapid removal of the chemotherapeutic agent from the IT compartment by aspiration and irrigation; however, it is unclear if neuroprotective agents may provide added benefit. Copyright (c) 2020 The Authors.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Medical Group
656 ## - INDEX TERM--OCCUPATION
Department Neurosurgery
657 ## - INDEX TERM--FUNCTION
Medline publication type Case Reports
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Felbaum, Daniel R
790 ## - Authors
All authors Felbaum D, Nair MN, Patel A, Soldozy S, Spitz SM, Syed HR, Yaeger K
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1016/j.ensci.2020.100297">https://dx.doi.org/10.1016/j.ensci.2020.100297</a>
Public note https://dx.doi.org/10.1016/j.ensci.2020.100297
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
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          MedStar Authors Catalog MedStar Authors Catalog 12/31/2020   33364452 33364452 12/31/2020 12/31/2020 Journal Article

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