MARC details
000 -LEADER |
fixed length control field |
03006nam a22003617a 4500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
201231s20212021 xxu||||| |||| 00| 0 eng d |
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
International Standard Serial Number |
2405-6502 |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
10.1016/j.ensci.2020.100297 [doi] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
PMC7750546 [pmc] |
024 ## - OTHER STANDARD IDENTIFIER |
Standard number or code |
S2405-6502(20)30076-9 [pii] |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
Ovid MEDLINE(R) |
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
PMID |
33364452 |
245 ## - TITLE STATEMENT |
Title |
Inadvertent intrathecal administration of daunomycin resulting in fatality: Case report and therapeutic considerations. |
251 ## - Source |
Source |
eNeurologicalSci. 22:100297, 2021 Mar. |
252 ## - Abbreviated Source |
Abbreviated source |
eNeurologicalSci. 22:100297, 2021 Mar. |
253 ## - Journal Name |
Journal name |
eNeurologicalSci |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Year |
2021 |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Manufacturer |
FY2021 |
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
Publication status |
epublish |
266 ## - Date added to catalog |
Date added to catalog |
2020-12-31 |
520 ## - SUMMARY, ETC. |
Abstract |
Background: Daunomycin is a chemotherapeutic agent of the anthracycline family that is administered intravenously, most commonly in combination therapy. The authors report the first known adult case of inadvertently administered daunomycin directly into the human central nervous system and the neurologic manifestations and therapeutic interventions that followed. |
520 ## - SUMMARY, ETC. |
Abstract |
Clinical description: A 53-year-old male presenting to the hospital for his second cycle of consolidation therapy for acute promyelocytic leukemia t(15;17) was accidentally administered 93 mg of intrathecal (IT) daunomycin. Within several hours of injection, the patient subsequently developed bilateral lower extremity pain, ascending paresthesias, headache, and left cranial nerve (CN) III palsy. Immediately following these neurologic sequalae, a subarachnoid lumbar drain was placed at the L4-5 interspace for the initial irrigation and drainage of cerebrospinal fluid (CSF). By hospital day 2, the patient's mental status significantly declined requiring an external ventricular drain (EVD) for hydrocephalus. Despite therapeutic interventions, the patient developed an ascending radiculomyeloencephalopathy with deterioration in clinical status. Eighteen days after the inadvertent injection of IT daunomycin, the patient became comatose and lost all cranial nerve function. |
520 ## - SUMMARY, ETC. |
Abstract |
Conclusions: Accidental IT injection of daunomycin is a neurosurgical emergency and warrants prompt intervention. Symptoms can mimic other medical conditions, making it imperative an accurate diagnosis is made so that appropriate therapies are implemented. At this time, therapies include rapid removal of the chemotherapeutic agent from the IT compartment by aspiration and irrigation; however, it is unclear if neuroprotective agents may provide added benefit. Copyright (c) 2020 The Authors. |
546 ## - LANGUAGE NOTE |
Language note |
English |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
Institution |
MedStar Medical Group |
656 ## - INDEX TERM--OCCUPATION |
Department |
Neurosurgery |
657 ## - INDEX TERM--FUNCTION |
Medline publication type |
Case Reports |
700 ## - ADDED ENTRY--PERSONAL NAME |
Local Authors |
Felbaum, Daniel R |
790 ## - Authors |
All authors |
Felbaum D, Nair MN, Patel A, Soldozy S, Spitz SM, Syed HR, Yaeger K |
856 ## - ELECTRONIC LOCATION AND ACCESS |
DOI |
<a href="https://dx.doi.org/10.1016/j.ensci.2020.100297">https://dx.doi.org/10.1016/j.ensci.2020.100297</a> |
Public note |
https://dx.doi.org/10.1016/j.ensci.2020.100297 |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Koha item type |
Journal Article |
Item type description |
Article |