Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. (Record no. 6310)

MARC details
000 -LEADER
fixed length control field 04508nam a22004217a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 210607s20212021 xxu||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1359-4184
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1038/s41380-021-01087-0 [doi]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1038/s41380-021-01087-0 [pii]
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
PMID 33859359
245 ## - TITLE STATEMENT
Title Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
251 ## - Source
Source Molecular Psychiatry. 26(11):6293-6304, 2021 11.
252 ## - Abbreviated Source
Abbreviated source Mol Psychiatry. 26(11):6293-6304, 2021 11.
252 ## - Abbreviated Source
Former abbreviated source Mol Psychiatry. 2021 Apr 15
253 ## - Journal Name
Journal name Molecular psychiatry
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Year 2021
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Manufacturer FY2021
265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE]
Publication status ppublish
266 ## - Date added to catalog
Date added to catalog 2021-06-07
268 ## - Previous citation
-- Molecular Psychiatry. 2021 Apr 15
520 ## - SUMMARY, ETC.
Abstract Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 Pjoint < 5 x 10-8), including rs7955964 (FIGNL2/ANKRD33) that increases BP among long sleepers, and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) that increase BP among short sleepers (Pint < 5 x 10-8). Secondary ancestry-specific analysis identified another novel gene by long sleep interaction at rs111887471 (TRPC3/KIAA1109) in individuals of African ancestry (Pint = 2 x 10-6). Combined stage 1 and 2 analyses additionally identified significant gene by long sleep interactions at 10 loci including MKLN1 and RGL3/ELAVL3 previously associated with BP, and significant gene by short sleep interactions at 10 loci including C2orf43 previously associated with BP (Pint < 10-3). 2df test also identified novel loci for BP after modeling sleep that has known functions in sleep-wake regulation, nervous and cardiometabolic systems. This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Genome-Wide Association Study
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element *Hypertension
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Blood Pressure/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Genetic Loci/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Hypertension/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Polymorphism, Single Nucleotide/ge [Genetics]
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Sleep/ge [Genetics]
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Institution MedStar Heart & Vascular Institutena
657 ## - INDEX TERM--FUNCTION
Medline publication type Journal Article
700 ## - ADDED ENTRY--PERSONAL NAME
Local Authors Barac, Ana
790 ## - Authors
All authors Alver M, Amin N, Arking DE, Aschard H, Barac A, Bartz TM, Bentley AR, Biermasz NR, Bis JC, Boerwinkle E, Bouchard C, Brown MR, Cade BE, Chen H, Chen YI, Chitrala K, de Vries PS, Deary IJ, Dorr M, Eiriksdottir G, Esko T, Evans MK, Fornage M, Fox ER, Franceschini N, Gao C, Gauderman WJ, Gharib SA, Gieger C, Gottlieb DJ, Grabe HJ, Gudnason V, Guo X, Hall KA, Harris SE, He J, Heikkinen S, Hillman DR, Horimoto AR, Ikram MA, Ilkov M, Kahonen M, Kelly TN, Kilpelainen TO, Komulainen P, Kooperberg C, Krieger JE, Kuhnel B, Lakka TA, Launer LJ, Lee J, Lehtimaki T, Levy D, Lim E, Liu CT, Liu Y, Lohman KK, Luik AI, Lyytikainen LP, Magi R, Manning AK, Martin LW, Meitinger T, Metspalu A, Milaneschi Y, Milani L, Mook-Kanamori DO, Morrison AC, Mukherjee S, Munroe PB, Musani SK, Nierenberg JL, Nolte IM, Noordam R, North KE, O'Connell J, Palmas W, Palmer LJ, Palmer ND, Penninx BWJH, Pereira AC, Peters A, Psaty BM, Rankinen T, Rao DC, Rauramaa R, Redline S, Rice K, Rice TK, Rich SS, Richard M, Roenneberg T, Rotter JI, Schreiner PJ, Schwander K, Shikany JM, Shu XO, Sidney S, Sims M, Snieder H, Sofer T, Starr JM, Strauch K, Sung YJ, Uitterlinden AG, van der Most PJ, van Duijn CM, van Heemst D, Vojinovic D, Volker U, Wagenknecht LE, Waken RJ, Waldenberger M, Wallace RB, Wang H, Weiss S, Wen W, Wilson G, Winkler TW, Xu H, Yao J, Zee PC, Zheng W, Zhu X, Zonderman AB
856 ## - ELECTRONIC LOCATION AND ACCESS
DOI <a href="https://dx.doi.org/10.1038/s41380-021-01087-0">https://dx.doi.org/10.1038/s41380-021-01087-0</a>
Public note https://dx.doi.org/10.1038/s41380-021-01087-0
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Item type description Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection Home library Current library Date acquired Total Checkouts Full call number Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 06/07/2021   33859359 33859359 06/07/2021 06/07/2021 Journal Article

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