MARC details
| 000 -LEADER |
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| fixed length control field |
04174nam a22005897a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210607s20212021 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
1434-7229 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s10047-021-01261-9 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s10047-021-01261-9 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
33792816 |
| 245 ## - TITLE STATEMENT |
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| Title |
VE/VCO2 slope predicts RV dysfunction and mortality after left ventricular assist device: a fresh look at cardiopulmonary stress testing for prognostication. |
| 251 ## - Source |
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| Source |
Journal of Artificial Organs. 24(4):425-432, 2021 Dec. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
J Artif Organs. 24(4):425-432, 2021 Dec. |
| 252 ## - Abbreviated Source |
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| Former abbreviated source |
J Artif Organs. 2021 Apr 01 |
| 253 ## - Journal Name |
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| Journal name |
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2021 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2022 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2021-06-07 |
| 268 ## - Previous citation |
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| -- |
Journal of Artificial Organs. 2021 Apr 01 |
| 269 ## - Original dates |
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| Original fiscal year |
FY2021 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Preoperative cardiopulmonary exercise testing (CPET) is well validated for prognostication before advanced surgical heart failure therapies, but its role in prognostication after LVAD surgery has never been studied. VE/VCO2 slope is an important component of CPET which has direct pathophysiologic links to right ventricular (RV) performance. We hypothesized that VE/VCO2 slope would prognosticate RV dysfunction after LVAD. All CPET studies from a single institution were collected between September 2009 and February 2019. Patients who ultimately underwent LVAD implantation were selectively analyzed. Peak VO2 and VE/VCO2 slope were measured for all patients. We evaluated their association with hemodynamic, echocardiographic and clinical markers of RV dysfunction as well mortality. Patients were stratified into those with a ventilatory class of III or greater. (VE/VCO2 slope of >= 36, n = 43) and those with a VE/VCO2 slope < 36 (n = 27). We compared the mortality between the 2 groups, as well as the hemodynamic, echocardiographic and clinical markers of RV dysfunction. 570 patients underwent CPET testing. 145 patients were ultimately referred to the advanced heart failure program and 70 patients later received LVAD implantation. Patients with VE/VCO2 slope of >= 36 had higher mortality (30.2% vs. 7.4%, p = 0.02) than patients with VE/VCO2 slope < 36 (n = 27). They also had a higher incidence of clinically important RVF (Acute severe 9.3% vs. 0%, Severe 32.6% vs 25.9%, p = 0.03). Patients with a VE/VCO2 slope >= 36 had a higher CVP than those with a lower VE/VCO2 slope (11.2 +/- 6.1 vs. 6.0 +/- 4.8 mmHg, p = 0.007), and were more likely to have a RA/PCWP >= 0.63 (65% vs. 19%, p = 0.008) and a PAPI <= 2 (57% vs. 13%, p = 0.008). In contrast, peak VO2 < 12 ml/kg/min was not associated with postoperative RV dysfunction or mortality. Elevated preoperative VE/VCO2 slope is a predictor of postoperative mortality, and is associated with postoperative clinical and hemodynamic markers of impaired RV performance. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Heart Failure |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Heart-Assist Devices |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Ventricular Dysfunction, Right |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Exercise Test |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Heart Failure/di [Diagnosis] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Oxygen Consumption |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Prognosis |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Internal Medicine Residency |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Medicine/General Internal Medicine |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Barnett, Christopher F |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Hofmeyer, Mark |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Kadakkal, Ajay |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Medvedofsky, Diego |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Molina, Ezequiel J |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Najjar, Samer S |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Rodrigo, Maria |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sawalha, Yazan |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sheikh, Farooq |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Zaghlol, Raja |
| 790 ## - Authors |
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| All authors |
Ahmad S, Barnett C, Grinstein J, Hofmeyer M, Kadakkal A, Kalantari S, Medvedofsky DA, Molina EJ, Najjar SS, Rodrigo M, Sawalha Y, Sheikh FH, Talati I, Zaghol R |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1007/s10047-021-01261-9">https://dx.doi.org/10.1007/s10047-021-01261-9</a> |
| Public note |
https://dx.doi.org/10.1007/s10047-021-01261-9 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
