MARC details
| 000 -LEADER |
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| fixed length control field |
03415nam a22003737a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
210628s20212021 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0937-941X |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s00198-021-05989-1 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1007/s00198-021-05989-1 [pii] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
34086101 |
| 245 ## - TITLE STATEMENT |
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| Title |
Long-term effects of lifestyle and metformin interventions in DPP on bone density. |
| 251 ## - Source |
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| Source |
Osteoporosis International. 2021 Jun 04 |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Osteoporos Int. 2021 Jun 04 |
| 253 ## - Journal Name |
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| Journal name |
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2021 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2021 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2021 Jun 04 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
aheadofprint |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2021-06-28 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: In a cohort at high risk of diabetes, lifestyle intervention or metformin did not appear to have long-term negative effects on BMD. Potential positive effects of metformin on bone warrant further research. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
In the Diabetes Prevention Program Outcome Study (DPPOS), a cohort at high risk of diabetes, randomization to intensive lifestyle intervention or metformin, both associated with weight loss, did not have long-term negative effects on BMD compared with the placebo group. Potential positive effects of metformin on bone warrant further investigation. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
INTRODUCTION: Randomization to lifestyle intervention (ILS) or metformin in the Diabetes Prevention Program (DPP) resulted in weight loss and reduced progression to diabetes. Weight loss is associated with reduced bone mineral density (BMD), but the long-term effects of these interventions on BMD are unknown. In the DPP Outcome Study (DPPOS), we determined if randomization to ILS or metformin, compared with placebo, was associated with differences in BMD approximately 16 years later. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: Of 3234 DPP participants, 2779 continued in DPPOS and were offered ILS in group format. Those randomized to metformin were offered unmasked metformin. At DPPOS year 12, 1367 participants had dual-energy X-ray absorptiometry scans. BMD in metformin and ILS groups was compared to placebo using sex-specific linear regression models, adjusted for age, race/ethnicity, and weight and weight-bearing activity at DPP baseline. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: At DPPOS year 12, mean age was 66.5 (+/-9.5) years. Femoral neck BMD was similar in the ILS and placebo groups in men (difference = -0.021 g/cm2, 95%CI (-0.063, 0.021)) and in women (+0.014 g/cm2, 95%CI (-0.014, 0.042)). Femoral neck BMD was higher in the metformin compared to placebo group although not statistically different in men (+0.017 g/cm2, 95% CI (-0.023, 0.058)) and in women (+0.019 g/cm2, 95% CI (-0.009, 0.047)). Prevalence of osteoporosis was low and similar across treatment groups in men (0.9%; p=0.745) and women (2.4%; p=0.466). |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Health Research Institute |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Aroda, Vanita R |
| 790 ## - Authors |
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| All authors |
Aroda VR, Crandall JP, Diabetes Prevention Program Research Group, Florez H, Kriska A, Pan Q, Piromalli C, Schwartz AV, Temprosa M, Wallia A |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1007/s00198-021-05989-1">https://dx.doi.org/10.1007/s00198-021-05989-1</a> |
| Public note |
https://dx.doi.org/10.1007/s00198-021-05989-1 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
Journal Article |
| Item type description |
Article |
