MARC details
| 000 -LEADER |
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| fixed length control field |
03527nam a22004577a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
211101s20212021 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
2666-0873 |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
34396339 |
| 245 ## - TITLE STATEMENT |
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| Title |
Left Ventricular Assist Devices in Patients With Active Malignancies. |
| 251 ## - Source |
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| Source |
JACC.CardioOncology. 3(2):305-315, 2021 Jun. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
JACC CardioOncol. 3(2):305-315, 2021 Jun. |
| 253 ## - Journal Name |
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| Journal name |
JACC. CardioOncology |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2021 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2021 |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
epublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2021-11-01 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Background: There are limited data to guide oncology and cardiology decision-making in patients with a left ventricular assist device (LVAD) and concurrent active malignancy. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Conclusions: Our study provides initial feasibility and safety data and set a framework for multidisciplinary team management of patients with cancer and LVADs. Copyright (c) 2021 The Authors. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Methods: In this retrospective cohort study, LVAD databases were reviewed to identify patients with a cancer diagnosis at the time of or after LVAD implantation. We created a 3:1 matched cohort based on age, sex, etiology of cardiomyopathy, LVAD implant strategy, and INTERMACS profile stratified by site. Kaplan-Meier analysis and Cox proportional hazards models were used to compare survival between patients with cancer and non-cancer comparators. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Objectives: The goal of this study was to describe cancer treatment approaches, complications, and survival among patients with active cancer on LVAD support in 2 tertiary heart failure and oncology programs. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
Results: Among 1,123 patients who underwent LVAD implantation between 2005 and 2019, 22 patients with LVADs with active cancer and 66 matched non-cancer comparators were identified. Median age was 62 years (range 41 to 73 years); 50% of patients with cancer were African-American, and 27% were women. Prostate cancer, followed by renal cell cancer and hematologic malignancies were the most common diagnoses. There was no significant difference in unadjusted Kaplan-Meier median survival estimates from the time of LVAD placement between patients with cancer (3.53 years; 95% confidence interval [CI]: 1.41 to 5.33) and non-cancer comparators (3.03 years; 95% CI: 1.83 to 5.26; log-rank P = 0.99). In Cox proportional hazard models, cancer diagnosis as a time-varying variable was associated with a statistically significant increase in death (hazard ratio: 2.05; 95% CI: 1.03 to 4.12; P = 0.04). Patients with cancer had less gastrointestinal bleeding compared with matched non-cancer comparators (P = 0.016). Other complications were not significantly different. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Heart & Vascular Institute |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
Washington Cancer Institute |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Cardiovascular Disease Fellowship |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Internal Medicine Residency |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Barac, Ana |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Basyal, Binaya |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Gallagher, Christopher |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Molina, Ezequiel |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Schlam, Ilana |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sheikh, Farooq |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Zaghlol, Raja |
| 790 ## - Authors |
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| All authors |
Barac A, Basyal B, Cheng RK, Gallagher C, Lee AY, Li S, Mahr C, Molina E, Schlam I, Sheikh FH, Zaghlol R |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1016/j.jaccao.2021.04.008">https://dx.doi.org/10.1016/j.jaccao.2021.04.008</a> |
| Public note |
https://dx.doi.org/10.1016/j.jaccao.2021.04.008 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
