The ED-SED Study: A Multicenter, Prospective Cohort Study of Practice Patterns and Clinical Outcomes Associated With Emergency Department SEDation for Mechanically Ventilated Patients. (Record no. 7999)

000 -LEADER
fixed length control field 03787nam a22007217a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190827s20192019 xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number 31393323
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0090-3493
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1097/CCM.0000000000003928 [doi]
190 ## -
-- Fuller BM
190 ## -
-- Roberts BW
190 ## -
-- Mohr NM
190 ## -
-- Knight WA 4th
190 ## -
-- Adeoye O
190 ## -
-- Pappal RD
190 ## -
-- Marshall S
190 ## -
-- Alunday R
190 ## -
-- Dettmer M
190 ## -
-- Goyal M
190 ## -
-- Gibson C
190 ## -
-- Levine BJ
190 ## -
-- Gardner-Gray JM
190 ## -
-- Mosier J
190 ## -
-- Dargin J
190 ## -
-- Mackay F
190 ## -
-- Johnson NJ
190 ## -
-- Lokhandwala S
190 ## -
-- Hough CL
190 ## -
-- Tonna JE
190 ## -
-- Tsolinas R
190 ## -
-- Lin F
190 ## -
-- Qasim ZA
190 ## -
-- Harvey CE
190 ## -
-- Bassin B
190 ## -
-- Stephens RJ
190 ## -
-- Yan Y
190 ## -
-- Carpenter CR
190 ## -
-- Kollef MH
190 ## -
-- Avidan MS
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Goyal, Munish
245 ## - TITLE STATEMENT
Title The ED-SED Study: A Multicenter, Prospective Cohort Study of Practice Patterns and Clinical Outcomes Associated With Emergency Department SEDation for Mechanically Ventilated Patients.
251 ## -
-- Critical Care Medicine. 2019 Aug 07
252 ## -
-- Crit Care Med. 2019 Aug 07
253 ## -
-- Critical care medicine
260 ## - PUBLICATION, DISTRIBUTION, ETC.
-- aheadofprint
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2019
269 ## -
-- FY2020
520 ## - SUMMARY, ETC.
Summary, etc. OBJECTIVES: To characterize emergency department sedation practices in mechanically ventilated patients, and test the hypothesis that deep sedation in the emergency department is associated with worse outcomes.
520 ## - SUMMARY, ETC.
Summary, etc. DESIGN: Multicenter, prospective cohort study.
520 ## - SUMMARY, ETC.
Summary, etc. SETTING: The emergency department and ICUs of 15 medical centers.
520 ## - SUMMARY, ETC.
Summary, etc. PATIENTS: Mechanically ventilated adult emergency department patients.
520 ## - SUMMARY, ETC.
Summary, etc. INTERVENTIONS: None.
520 ## - SUMMARY, ETC.
Summary, etc. MEASUREMENTS AND MAIN RESULTS: All data involving sedation (medications, monitoring) were recorded. Deep sedation was defined as Richmond Agitation-Sedation Scale of -3 to -5 or Sedation-Agitation Scale of 2 or 1. A total of 324 patients were studied. Emergency department deep sedation was observed in 171 patients (52.8%), and was associated with a higher frequency of deep sedation in the ICU on day 1 (53.8% vs 20.3%; p < 0.001) and day 2 (33.3% vs 16.9%; p = 0.001), when compared to light sedation. Mean (SD) ventilator-free days were 18.1 (10.8) in the emergency department deep sedation group compared to 20.0 (9.8) in the light sedation group (mean difference, 1.9; 95% CI, -0.40 to 4.13). Similar results according to emergency department sedation depth existed for ICU-free days (mean difference, 1.6; 95% CI, -0.54 to 3.83) and hospital-free days (mean difference, 2.3; 95% CI, 0.26-4.32). Mortality was 21.1% in the deep sedation group and 17.0% in the light sedation group (between-group difference, 4.1%; odds ratio, 1.30; 0.74-2.28). The occurrence rate of acute brain dysfunction (delirium and coma) was 68.4% in the deep sedation group and 55.6% in the light sedation group (between-group difference, 12.8%; odds ratio, 1.73; 1.10-2.73).
520 ## - SUMMARY, ETC.
Summary, etc. CONCLUSIONS: Early deep sedation in the emergency department is common, carries over into the ICU, and may be associated with worse outcomes. Sedation practice in the emergency department and its association with clinical outcomes is in need of further investigation.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
656 ## - INDEX TERM--OCCUPATION
Occupation Emergency Medicine
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name MedStar Washington Hospital Center
657 ## - INDEX TERM--FUNCTION
Function Journal Article
857 ## -
-- https://dx.doi.org/10.1097/CCM.0000000000003928
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection code Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 2019-08-27 31393323 2019-08-27 2019-08-27 Journal Article

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