A Dangerous and Unrecognized Interaction of Apixaban. (Record no. 894)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01801nam a22003257a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220221s20212021 xxu||||| |||| 00| 0 eng d |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | 10.7759/cureus.19688 [doi] |
| 024 ## - OTHER STANDARD IDENTIFIER | |
| Standard number or code | PMC8683972 [pmc] |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| PMID | 34934565 |
| 245 ## - TITLE STATEMENT | |
| Title | A Dangerous and Unrecognized Interaction of Apixaban. |
| 251 ## - Source | |
| Source | Cureus. 13(11):e19688, 2021 Nov. |
| 252 ## - Abbreviated Source | |
| Abbreviated source | Cureus. 13(11):e19688, 2021 Nov. |
| 253 ## - Journal Name | |
| Journal name | Cureus |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Year | 2021 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Manufacturer | FY2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Publication date | 2021 Nov |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] | |
| Publication status | epublish |
| 266 ## - Date added to catalog | |
| Date added to catalog | 2022-02-21 |
| 520 ## - SUMMARY, ETC. | |
| Abstract | Direct oral anticoagulants (DOACs) drug-to-drug interactions are underrecognized by clinicians. Apixaban has cytochrome 450 (CYP) mediated metabolism (primarily by CYP3A4). Strong inducers and inhibitors of this enzyme may cause variations in the blood level of apixaban. This report presents a patient who received a femoral artery stent and developed a large retroperitoneal hemorrhage after she was prescribed apixaban in addition to her antiretroviral therapy (AVT) regimen that included cobicistat, a strong CYP3A4 inhibitor. The patient was managed conservatively, and a repeat computed tomography scan in a subsequent admission revealed near resolution of the hematoma. The treating physicians realized that apixaban should not be prescribed with a potent CYP3A4 inhibitor like cobicistat and discontinued it. Copyright (c) 2021, Ammar et al. |
| 546 ## - LANGUAGE NOTE | |
| Language note | English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | IN PROCESS -- NOT YET INDEXED |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME | |
| Institution | MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION | |
| Department | Medicine/Internal Medicine |
| 657 ## - INDEX TERM--FUNCTION | |
| Medline publication type | Case Reports |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Local Authors | Ammar, Hussam |
| 790 ## - Authors | |
| All authors | Ammar H, Govindu RR |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| DOI | <a href="https://dx.doi.org/10.7759/cureus.19688">https://dx.doi.org/10.7759/cureus.19688</a> |
| Public note | https://dx.doi.org/10.7759/cureus.19688 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Journal Article |
| Item type description | Article |
| Withdrawn status | Lost status | Damaged status | Not for loan | Collection | Home library | Current library | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MedStar Authors Catalog | MedStar Authors Catalog | 02/21/2022 | 34934565 | 34934565 | 02/21/2022 | 02/21/2022 | Journal Article |