MARC details
| 000 -LEADER |
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| fixed length control field |
03731nam a22005777a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
220124s20212021 xxu||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER |
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| International Standard Serial Number |
0269-2813 |
| 024 ## - OTHER STANDARD IDENTIFIER |
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| Standard number or code |
10.1111/apt.16659 [doi] |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Ovid MEDLINE(R) |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| PMID |
34850415 |
| 245 ## - TITLE STATEMENT |
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| Title |
Systematic review with meta-analysis: the impact of functional cure on clinical outcomes in patients with chronic hepatitis B. |
| 251 ## - Source |
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| Source |
Alimentary Pharmacology & Therapeutics. 55(1):8-25, 2022 01. |
| 252 ## - Abbreviated Source |
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| Abbreviated source |
Aliment Pharmacol Ther. 55(1):8-25, 2022 01. |
| 252 ## - Abbreviated Source |
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| Former abbreviated source |
Aliment Pharmacol Ther. 55(1):8-25, 2022 01. |
| 252 ## - Abbreviated Source |
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| Former abbreviated source |
Aliment Pharmacol Ther. 55(1):8-25, 2022 Jan. |
| 253 ## - Journal Name |
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| Journal name |
Alimentary pharmacology & therapeutics |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Year |
2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Manufacturer |
FY2022 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Publication date |
2022 Jan |
| 265 ## - SOURCE FOR ACQUISITION/SUBSCRIPTION ADDRESS [OBSOLETE] |
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| Publication status |
ppublish |
| 266 ## - Date added to catalog |
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| Date added to catalog |
2022-01-25 |
| 268 ## - Previous citation |
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| -- |
Alimentary Pharmacology & Therapeutics. 55(1):8-25, 2022 01. |
| 268 ## - Previous citation |
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| -- |
Alimentary Pharmacology & Therapeutics. 55(1):8-25, 2022 Jan. |
| 269 ## - Original dates |
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| Original fiscal year |
FY2022 |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
AIM: To assess the impact of HBsAg loss on clinical outcomes following spontaneous and treatment-related HBsAg loss. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
BACKGROUND: Although hepatitis B surface antigen (HBsAg) loss is considered the ideal therapeutic endpoint for the treatment of chronic hepatitis B virus (HBV) infection, its impact on clinical outcomes remains uncertain. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
CONCLUSION: HBsAg loss is associated with a reduced risk of clinical outcomes. However, several shortcomings in the published studies prevent a more definitive conclusion on the potential benefits of HBsAg loss. Copyright (c) 2021 John Wiley & Sons Ltd. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
METHODS: We searched PUBMED, Embase, the Cochrane library, and published abstracts through to May 2021 for studies that reported HBsAg loss, had >1 year of follow-up and reported at least one clinical outcome in adults with chronic HBV infection. |
| 520 ## - SUMMARY, ETC. |
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| Abstract |
RESULTS: We identified 57 studies (258 744 HBsAg-positive patients, 63 270 with HBsAg loss). Based on 24 studies including 160 598 patients with and without HBsAg loss, HBsAg loss was associated with a non-significant 23% relative risk reduction of developing hepatocellular carcinoma (HCC) compared to those who remained HBsAg-positive (RR = 0.77; 95% CI: 0.38-1.57). In subgroup meta-analysis of 10 studies, treatment-related HBsAg loss was associated with a non-significant higher pooled proportion of HCC (0.94%) compared to spontaneous HBsAg loss (0.45%). HCC development after HBsAg loss was significantly higher in males, those with underlying cirrhosis, and those with a family history of HCC. HBsAg loss was associated with lower pooled proportions of incident cirrhosis, hepatic decompensation, overall and liver-related mortality compared to no HBsAg loss. Substantial heterogeneity was noted across studies for all outcomes. |
| 546 ## - LANGUAGE NOTE |
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| Language note |
English |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Carcinoma, Hepatocellular |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Hepatitis B |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Hepatitis B, Chronic |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
*Liver Neoplasms |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Adult |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Carcinoma, Hepatocellular/ep [Epidemiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Carcinoma, Hepatocellular/et [Etiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Hepatitis B Surface Antigens |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Hepatitis B virus |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Hepatitis B, Chronic/dt [Drug Therapy] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Humans |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Liver Neoplasms/ep [Epidemiology] |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Male |
| 651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME |
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| Institution |
MedStar Washington Hospital Center |
| 656 ## - INDEX TERM--OCCUPATION |
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| Department |
Internal Medicine Residency |
| 657 ## - INDEX TERM--FUNCTION |
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| Medline publication type |
Journal Article |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Local Authors |
Sharma, Disha |
| 790 ## - Authors |
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| All authors |
Auh S, Ghany MG, Hu A, Majeed NA, Sharma D, Terry N, Vittal A |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| DOI |
<a href="https://dx.doi.org/10.1111/apt.16659">https://dx.doi.org/10.1111/apt.16659</a> |
| Public note |
https://dx.doi.org/10.1111/apt.16659 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Koha item type |
Journal Article |
| Item type description |
Article |
