Comorbidities Drive the Majority of Overall Mortality in Low-risk Mucinous Pancreatic Cysts under Surveillance. (Record no. 9950)

000 -LEADER
fixed length control field 03380nam a22004577a 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 201231s20202020 xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency Ovid MEDLINE(R)
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number 33309984
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1542-3565
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code S1542-3565(20)31665-7 [pii]
024 ## - OTHER STANDARD IDENTIFIER
Standard number or code 10.1016/j.cgh.2020.12.008 [doi]
190 ## -
-- Chhoda A
190 ## -
-- Yousaf MN
190 ## -
-- Madhani K
190 ## -
-- Aslanian H
190 ## -
-- Jamidar PA
190 ## -
-- Suarez AL
190 ## -
-- Salem RA
190 ## -
-- Muniraj T
190 ## -
-- Kunstman J
190 ## -
-- Farrell JJ
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Yousaf, Muhammad N
245 ## - TITLE STATEMENT
Title Comorbidities Drive the Majority of Overall Mortality in Low-risk Mucinous Pancreatic Cysts under Surveillance.
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-- Clinical Gastroenterology & Hepatology. 2020 Dec 10
252 ## -
-- Clin Gastroenterol Hepatol. 2020 Dec 10
253 ## -
-- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
260 ## - PUBLICATION, DISTRIBUTION, ETC.
-- aheadofprint
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2020
269 ## -
-- FY2021
520 ## - SUMMARY, ETC.
Summary, etc. BACKGROUND & AIMS: The Charlson Comorbidity Index (CACI) has been suggested as a tool to determine comorbidity burden and guide management for patients with mucinous pancreatic cysts (Intrapapillary Mucinous Neoplasms and Mucinous Cystic Neoplasms), but has not been studied well among "low-risk" mucinous pancreatic cysts i.e. without worrisome features (WF) and high-risk stigmata (HRS). This study sought to determine the comorbidity burden among surveillance population of low-risk pancreatic cysts and provide their follow-up mortality outcomes.
520 ## - SUMMARY, ETC.
Summary, etc. METHODS: A single center study retrospectively reviewed a prospective pancreatic cyst database and included individuals with low-risk cysts undergoing serial imaging during 2016. Electronic medical records were reviewed to determine their baseline age-adjusted CACI (age-CACI). After 4 years, their progression to WF, disease specific (pancreatic malignancy-related, DSM), extra-pancreatic (EPM), and overall mortalities (OM) were determined using Kaplan-Meir Survival Analysis.
520 ## - SUMMARY, ETC.
Summary, etc. RESULTS: 502 individuals underwent prospective surveillance. The study included 440 individuals with low-risk suspected or presumed mucinous cysts and excluded 50 and 12 individuals with WF and HRS respectively. Over a median follow-up of 56 months, 12 WF progressions, 2 DSMs, 42 EPMs, and 44 OMs were observed. Baseline age-CACI had good predictive capacity for 4-year EPM (Area-Under Curve: 0.87; p<.0001). The median age-CACI of 4 enabled cohort stratification into Low (age-CACI <4) and High CACI (age-CACI >=4) groups. A significantly higher OM (p<.001) was observed among the High CACI group as compared to the Low CACI group.
520 ## - SUMMARY, ETC.
Summary, etc. CONCLUSION: Through real-time application of CACI to patient outcomes, our analysis supports incorporation of this comorbidity assessment tool in making shared surveillance decisions among low-risk pancreatic cyst population. Copyright (c) 2020 AGA Institute. Published by Elsevier Inc. All rights reserved.
546 ## - LANGUAGE NOTE
Language note English
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element IN PROCESS -- NOT YET INDEXED
651 ## - SUBJECT ADDED ENTRY--GEOGRAPHIC NAME
Geographic name MedStar Union Memorial Hospital
657 ## - INDEX TERM--FUNCTION
Function Journal Article
857 ## -
-- https://dx.doi.org/10.1016/j.cgh.2020.12.008
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier https://dx.doi.org/10.1016/j.cgh.2020.12.008
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Koha item type Journal Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Collection code Permanent Location Current Location Date acquired Barcode Date last seen Price effective from Koha item type
          MedStar Authors Catalog MedStar Authors Catalog 2020-12-31 33309984 2020-12-31 2020-12-31 Journal Article

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