MedStar Authors catalog › Details for: Dobutamine stress echocardiography in patients undergoing orthotopic liver transplantation: a pooled analysis of accuracy, perioperative and long term cardiovascular prognosis. [Review]
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Dobutamine stress echocardiography in patients undergoing orthotopic liver transplantation: a pooled analysis of accuracy, perioperative and long term cardiovascular prognosis. [Review]

by Taylor, Allen J.
Citation: The International Journal of Cardiovascular Imaging. 29(8):1741-8, 2013 Dec..Journal: The international journal of cardiovascular imaging.ISSN: 1569-5794.Full author list: Nguyen P; Plotkin J; Fishbein TM; Laurin JM; Satoskar R; Shetty K; Taylor AJ.UI/PMID: 23974907.Subject(s): Cardiovascular Diseases/et [Etiology] | Cardiovascular Diseases/mo [Mortality] | *Cardiovascular Diseases/us [Ultrasonography] | *Coronary Artery Disease/us [Ultrasonography] | *Echocardiography, Stress | Humans | Liver Transplantation/ae [Adverse Effects] | Liver Transplantation/mo [Mortality] | *Liver Transplantation | Predictive Value of Tests | Preoperative Care | Risk Factors | Time Factors | Treatment OutcomeInstitution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Meta-Analysis | ReviewDigital Object Identifier: http://dx.doi.org/10.1007/s10554-013-0275-x (Click here) Abbreviated citation: Int J Cardiovasc Imaging. 29(8):1741-8, 2013 Dec.Abstract: Pre-transplant evaluation for orthotopic liver transplantation (OLT) commonly includes a cardiac evaluation using dobutamine stress echocardiography (DSE). We performed a quantitative systematic review assessing DSE's use in detecting coronary artery disease (CAD) and predicting perioperative and long term cardiac events in patients undergoing OLT. Published studies in pubmed were accessed using keyword searches and bibliographic review. Included studies evaluated the use of DSE in patients undergoing OLT, including its accuracy for detection of CAD, and in predicting perioperative and long term cardiac prognosis for both hard (myocardial infarction, cardiac death, cardiac arrest, and asystole) and soft cardiac events (all other events that were cardiovascular in nature). We calculated DSE's sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) in the above areas. We identified 7 studies, including a total of 580 patients, which included 4 accuracy studies (n = 110 patients), 4 perioperative studies, and 3 long term studies. Accuracy for CAD included a sensitivity of 0.32, specificity of 0.78, PPV of 0.37, and NPV of 0.75. Accuracy for prediction of perioperative hard and soft cardiac events was a sensitivity of 0.20 and 0, specificity of 0.99 and 0.99, PPV of 0.33 and 0, and NPV of 0.98 and 0.89, respectively. For long term hard and soft cardiac events, sensitivity was 0.5 and 0, specificity 0.99 and 0.98, PPV 0.33 and 0, and NPV 0.99 and 0.96, respectively. DSE has a limited accuracy for the detection of CAD in candidates for OLT. However, among those patients selected for OLT, the negative predictive value of DSE for both perioperative and long term cardiac events is high.

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