Comparison of Cone-Beam Tomography and Cross-Sectional Imaging for Volumetric and Dosimetric Calculations in Resin Yttrium-90 Radioembolization.

MedStar author(s):
Citation: Cardiovascular & Interventional Radiology. 41(12):1857-1866, 2018 Dec.PMID: 30006891Institution: MedStar Washington Hospital CenterDepartment: RadiologyForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Brachytherapy/mt [Methods] | *Cone-Beam Computed Tomography/mt [Methods] | *Liver Neoplasms/rt [Radiotherapy] | *Magnetic Resonance Imaging/mt [Methods] | *Radiotherapy Planning, Computer-Assisted/mt [Methods] | *Yttrium Radioisotopes/tu [Therapeutic Use] | Adult | Aged | Aged, 80 and over | Contrast Media | Female | Humans | Image Enhancement/mt [Methods] | Liver Neoplasms/dg [Diagnostic Imaging] | Liver Neoplasms/pa [Pathology] | Liver/dg [Diagnostic Imaging] | Liver/pa [Pathology] | Liver/re [Radiation Effects] | Male | Middle Aged | Multimodal Imaging/mt [Methods] | Organ Size | Radiotherapy Dosage | Retrospective Studies | Tomography, X-Ray Computed/mt [Methods]Year: 2018ISSN:
  • 0174-1551
Name of journal: Cardiovascular and interventional radiologyAbstract: CONCLUSIONS: Although volume measurements derived from CT/MRI did not differ significantly from those derived from CBCT, variability between the two methods led to large and unexpected differences in calculated dose.MATERIALS AND METHODS: The study retrospectively assessed 47 consecutive patients who underwent resin Y-90 radioembolization consecutively over a 2-year period at a single center. Volume calculation software was used to determine perfused lobar liver volumes from cone-beam CT (CBCT) images obtained during mapping angiography. CBCT-derived volumes were compared with perfused lobar volume derived from contrast-enhanced CT and MRI. Nominal activities as determined by the SIR-Spheres Microspheres Activity Calculator were similarly calculated and compared using both CBCT and conventionally acquired volumes.PURPOSE: To compare the use of cone-beam computed tomography versus contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the calculation of liver volume and planned dose for yttrium-90 radioembolization.RESULTS: A total of 82 hepatic lobes were assessed in 47 patients. The mean percentage difference between combined CT-MRI- and CBCT-derived calculated lobar volumes was 25.3% (p=0.994). The mean percentage difference in calculated dose between the two methods was 21.8+/-24.6% (p=0.42). Combined left and right lobar CT-derived dose difference was less than 10% in 22 lobes, between 10 and 25% in 20 lobes, between 25 and 50% in 13 lobes and greater than 50% in 5 lobes. Combined left and right lobar MRI-derived dose difference was less than 10% in 11 lobes, between 10 and 25% in 7 lobes, between 25 and 50% in 2 lobes and greater than 50% in 1 lobe.All authors: Buckley D, Caridi T, Choi H, Cohen E, Ertreo M, Field D, Kim AY, Lischalk JW, Lynskey GE, Unger KFiscal year: FY2019Digital Object Identifier: ORCID: Date added to catalog: 2018-07-30
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Journal Article MedStar Authors Catalog Article 30006891 Available 30006891

CONCLUSIONS: Although volume measurements derived from CT/MRI did not differ significantly from those derived from CBCT, variability between the two methods led to large and unexpected differences in calculated dose.

MATERIALS AND METHODS: The study retrospectively assessed 47 consecutive patients who underwent resin Y-90 radioembolization consecutively over a 2-year period at a single center. Volume calculation software was used to determine perfused lobar liver volumes from cone-beam CT (CBCT) images obtained during mapping angiography. CBCT-derived volumes were compared with perfused lobar volume derived from contrast-enhanced CT and MRI. Nominal activities as determined by the SIR-Spheres Microspheres Activity Calculator were similarly calculated and compared using both CBCT and conventionally acquired volumes.

PURPOSE: To compare the use of cone-beam computed tomography versus contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) in the calculation of liver volume and planned dose for yttrium-90 radioembolization.

RESULTS: A total of 82 hepatic lobes were assessed in 47 patients. The mean percentage difference between combined CT-MRI- and CBCT-derived calculated lobar volumes was 25.3% (p=0.994). The mean percentage difference in calculated dose between the two methods was 21.8+/-24.6% (p=0.42). Combined left and right lobar CT-derived dose difference was less than 10% in 22 lobes, between 10 and 25% in 20 lobes, between 25 and 50% in 13 lobes and greater than 50% in 5 lobes. Combined left and right lobar MRI-derived dose difference was less than 10% in 11 lobes, between 10 and 25% in 7 lobes, between 25 and 50% in 2 lobes and greater than 50% in 1 lobe.

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