MedStar Authors catalog › Details for: Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study.
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Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study.

by Zhu, Jianhui; Howard, Barbara V.
Citation: Genetic Epidemiology. 37(7):751-7, 2013 Nov..Journal: Genetic epidemiology.ISSN: 0741-0395.Full author list: Rubicz R; Zhu J; Laston S; Cole SA; Voruganti VS; Ebbesson SO; Howard BV; Maccluer JW; Davidson M; Umans JG; Comuzzie AG; Goring HH.UI/PMID: 23798484.Subject(s): Adolescent | Adult | Age Factors | Aged | Aged, 80 and over | Alaska | *Antibodies, Bacterial/bl [Blood] | *Antibodies, Viral/bl [Blood] | C-Reactive Protein/an [Analysis] | Chlamydophila pneumoniae/im [Immunology] | Chlamydophila pneumoniae/ip [Isolation & Purification] | Chromosomes, Human, Pair 15/ge [Genetics] | Chronic Disease | *Coronary Artery Disease/ge [Genetics] | Coronary Artery Disease/mi [Microbiology] | Coronary Artery Disease/vi [Virology] | Cytomegalovirus/im [Immunology] | Cytomegalovirus/ip [Isolation & Purification] | Female | Genetic Linkage/ge [Genetics] | Genetic Predisposition to Disease/ge [Genetics] | Genome, Human/ge [Genetics] | *Health Surveys | Helicobacter pylori/im [Immunology] | Helicobacter pylori/ip [Isolation & Purification] | Herpesvirus 1, Human/im [Immunology] | Herpesvirus 1, Human/ip [Isolation & Purification] | Herpesvirus 2, Human/im [Immunology] | Herpesvirus 2, Human/ip [Isolation & Purification] | Humans | Immunoglobulin G/bl [Blood] | *Indians, North American/ge [Genetics] | *Infection/ge [Genetics] | *Infection/im [Immunology] | Infection/mi [Microbiology] | Infection/vi [Virology] | Lod Score | Male | Middle Aged | Pedigree | Seroepidemiologic Studies | Serologic Tests | Time Factors | Young AdultInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tDigital Object Identifier: (Click here) Abbreviated citation: Genet Epidemiol. 37(7):751-7, 2013 Nov.Abstract: This paper describes genetic investigations of seroreactivity to five common infectious pathogens in the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) study. Antibody titers and seroprevalence were available for 495 to 782 (depending on the phenotype) family members at two time points, approximately 15 years apart, for Chlamydophila pneumoniae, Helicobacter pylori, cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and herpes simplex virus 2 (HSV-2). Seroprevalence rates indicate that infections with most of these pathogens are common (>20% for all of them, >80% for H. pylori, CMV, and HSV-1). Seropositive individuals typically remain seropositive over time, with seroreversion rates of <1% to 10% over ~15 years. Antibody titers were significantly heritable for most pathogens, with the highest estimate being 0.61 for C. pneumoniae. Significant genome-wide linkage evidence was obtained for C. pneumoniae on chromosome 15 (logarithm of odds, LOD score of 3.13). These results demonstrate that individual host genetic differences influence antibody measures of common infections in this population, and further investigation may elucidate the underlying immunological processes and genes involved. 2013 WILEY PERIODICALS, INC.

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