MedStar Authors catalog › Details for: Bioresorbable scaffolds: rationale, current status, challenges, and future. [Review]
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Bioresorbable scaffolds: rationale, current status, challenges, and future. [Review]

by Waksman, Ron.
Citation: European Heart Journal. 35(12):765-76, 2014 Mar..Journal: European heart journal.ISSN: 0195-668X.Full author list: Iqbal J; Onuma Y; Ormiston J; Abizaid A; Waksman R; Serruys P.UI/PMID: 24366915.Subject(s): *Absorbable Implants/td [Trends] | Blood Vessel Prosthesis | Clinical Trials as Topic | Coronary Stenosis/th [Therapy] | Drug-Eluting Stents | Forecasting | Graft Occlusion, Vascular/pc [Prevention & Control] | Humans | Metals/tu [Therapeutic Use] | Prosthesis Design | *Tissue Scaffolds/td [Trends]Institution(s): MedStar Heart & Vascular InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, Non-U.S. Gov't | ReviewOnline resources: Click here to access online Digital Object Identifier: http://dx.doi.org/10.1093/eurheartj/eht542 (Click here) Abbreviated citation: Eur Heart J. 35(12):765-76, 2014 Mar.Local Holdings: Available online from MWHC library: 1996 - present (after 1 year), Available in print through MWHC library: 1999 - 2006.Abstract: Current generation of drug-eluting stents has significantly improved the outcomes of percutaneous coronary intervention by substantially reducing in-stent restenosis and stent thrombosis. However, a potential limitation of these stents is the permanent presence of a metallic foreign body within the artery, which may cause vascular inflammation, restenosis, thrombosis, and neoatherosclerosis. The permanent stents also indefinitely impair the physiological vasomotor function of the vessel and future potential of grafting the stented segment. Bioresorbable scaffolds (BRSs) have the potential to overcome these limitations as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage and restoring pulsatility, cyclical strain, physiological shear stress, and mechanotransduction. While a number of BRSs are under development, two devices with substantial clinical data have already received a Conformite Europeenne marking. This review article presents the current status of these devices and evaluates the challenges that need to be overcome before BRSs can become the workhorse device in coronary intervention.

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