Post-ischemic hyperemia following endovascular therapy for acute stroke is associated with lesion growth.
Citation: Journal of Cerebral Blood Flow & Metabolism. 43(6):856-868, 2023 Jun.PMID: 36748316Institution: MedStar Washington Hospital CenterDepartment: Comprehensive Stroke CenterForm of publication: Journal ArticleMedline article type(s): Journal ArticleSubject headings: *Brain Ischemia | *Endovascular Procedures | *Hyperemia | *Reperfusion Injury | *Stroke | Brain Ischemia/dg [Diagnostic Imaging] | Brain Ischemia/dt [Drug Therapy] | Brain Ischemia/su [Surgery] | Endovascular Procedures/ae [Adverse Effects] | Female | Humans | Male | Stroke/dt [Drug Therapy] | Stroke/su [Surgery] | Thrombectomy | Thrombolytic Therapy | Treatment Outcome | Year: 2023ISSN:- 0271-678X
A substantial proportion of acute stroke patients fail to recover following successful endovascular therapy (EVT) and injury to the brain and vasculature secondary to reperfusion may be a contributor. Acute stroke patients were included with: i) large vessel occlusion of the anterior circulation, ii) successful recanalization, and iii) evaluable MRI early after EVT. Presence of hyperemia on MRI perfusion was assessed by consensus using a modified ASPECTS. Three different approaches were used to quantify relative cerebral blood flow (rCBF). Sixty-seven patients with median age of 66 [59-76], 57% female, met inclusion criteria. Hyperemia was present in 35/67 (52%) patients early post-EVT, in 32/65 (49%) patients at 24 hours, and in 19/48 (40%) patients at 5 days. There were no differences in incomplete reperfusion, HT, PH-2, HARM, severe HARM or symptomatic ICH rates between those with and without early post-EVT hyperemia. A strong association (R2 = 0.81, p < 0.001) was found between early post-EVT hyperemia (p = 0.027) and DWI volume at 24 hours after adjusting for DWI volume at 2 hours (p < 0.001) and incomplete reperfusion at 24 hours (p = 0.001). Early hyperemia is a potential marker for cerebrovascular injury and may help select patients for adjunctive therapy to prevent edema, reperfusion injury, and lesion growth.
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