Citation: Nutrition Metabolism & Cardiovascular Diseases. 24(12):1360-4, 2014 Dec..Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD.ISSN: 0939-4753.Full author list: Ferrara LA; Wang H; Umans JG; Franceschini N; Jolly S; Lee ET; Yeh J; Devereux RB; Howard BV; de Simone G.UI/PMID: 25063537.Subject(s): Aged | Body Composition | Body Mass Index | Cohort Studies | Female | Humans | Hypertension/ep [Epidemiology] | Indians, North American | Male | *Metabolic Syndrome X/bl [Blood] | *Metabolic Syndrome X/ep [Epidemiology] | Middle Aged | *Obesity/bl [Blood] | *Obesity/ep [Epidemiology] | Obesity, Abdominal/ep [Epidemiology] | Predictive Value of Tests | Prevalence | Prospective Studies | Sex Factors | *Uric Acid/bl [Blood] | Waist-Hip RatioInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralDigital Object Identifier: http://dx.doi.org/10.1016/j.numecd.2014.06.002 (Click here)Abbreviated citation: Nutr Metab Cardiovasc Dis. 24(12):1360-4, 2014 Dec.Abstract: AIM: To evaluate whether uric acid (UA) predicts 4-yr incidence of metabolic syndrome (MetS) in non-diabetic participants of the Strong Heart Study (SHS) cohort.Abstract: METHODS AND RESULTS: In this population-based prospective study we analyzed 1499 American Indians (890 women), without diabetes or MetS, controlled during the 4th SHS exam and re-examined 4 years later during the 5th SHS exam. Participants were divided into sex-specific tertiles of UA and the first two tertiles (group N) were compared with the third tertile (group H). Body mass index (BMI = 28.3 +/- 7 vs. 31.1 +/- 7 kg/m(2)), fat-free mass (FFM = 52.0 +/- 14 vs. 54.9 +/- 11 kg), waist-to-hip ratio, HOMA-IR (3.66 vs. 4.26), BP and indices of inflammation were significantly higher in group H than in group N (all p < 0.001). Incident MetS at the time of the 5th exam was more frequent in group H than group N (35 vs. 28%, OR 1.44 (95% CI = 1.10-1.91; p < 0.01). This association was still significant (OR = 1.13, p = 0.04) independently of family relatedness, sex, history of hypertension, HOMA-IR, central adiposity and renal function, but disappeared when fat-free mass was included in the model.Abstract: CONCLUSIONS: In the SHS, UA levels are associated to parameters of insulin resistance and to indices of inflammation. UA levels, however, do not predict incident MetS independently of the initial obesity-related increased FFM.Copyright � 2014 Elsevier B.V. All rights reserved.