The association of cord serum cytokines with neurodevelopmental outcomes.

MedStar author(s):
Citation: American Journal of Perinatology. 30(2):115-22, 2015 Feb.PMID: 24936937Institution: MedStar Washington Hospital CenterDepartment: Obstetrics and Gynecology, Maternal-Fetal MedicineForm of publication: Journal ArticleMedline article type(s): Journal Article | Randomized Controlled Trial | Research Support, N.I.H., ExtramuralSubject headings: *Cerebral Palsy/bl [Blood] | *Cytokines/bl [Blood] | *Developmental Disabilities/bl [Blood] | *Fetal Blood/me [Metabolism] | *Interleukin-1beta/bl [Blood] | *Interleukin-8/bl [Blood] | *Premature Birth/bl [Blood] | *Tumor Necrosis Factor-alpha/bl [Blood] | Adult | Case-Control Studies | Cerebral Palsy/di [Diagnosis] | Cerebral Palsy/pc [Prevention & Control] | Child Development | Child, Preschool | Developmental Disabilities/di [Diagnosis] | Female | Humans | Infant | Infant, Newborn | Infant, Premature | Logistic Models | Magnesium Sulfate/tu [Therapeutic Use] | Pregnancy | Prognosis | Tocolytic Agents/tu [Therapeutic Use] | Young AdultYear: 2015ISSN:
  • 0735-1631
Name of journal: American journal of perinatologyAbstract: CONCLUSION: Cord serum IL-8, IL-1beta, and TNF-alpha levels in preterm infants are not associated with subsequent CP or NDD.Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.OBJECTIVE: To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD).RESULTS: Logistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1beta were more common in cord blood serum from infants with subsequent low MDI as compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1beta, and TNF-alpha) were not elevated with CP or low PDI.STUDY DESIGN: Nested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated preterm birth (PTB) for prevention of CP, with evaluation of surviving children at the age of 2. NDD was defined as a Bayley psychomotor developmental index (PDI) and/or mental developmental index (MDI)<70. Controls, defined as surviving children without CP and with Bayley PDI and MDI>85, were matched by race and gestational age. Cord serum was analyzed for interleukin-8 (IL-8) interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. Elevated cytokine levels were defined as>75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity, and sociodemographic differences.All authors: ; for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network, Caritis SN, Carpenter M, Dudley DJ, Hankins GD, Iams JD, Jablonski KA, Leveno KJ, Malone FD, Marshall NE, Mercer BM, O'Sullivan MJ, Peaceman AM, Reddy UM, Rouse DJ, Sorokin Y, Thorp JM, Varner MW, Wapner RJFiscal year: FY2015Digital Object Identifier: Date added to catalog: 2016-01-13
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 24936937 Available 24936937

CONCLUSION: Cord serum IL-8, IL-1beta, and TNF-alpha levels in preterm infants are not associated with subsequent CP or NDD.Copyright Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

OBJECTIVE: To test whether elevated umbilical cord serum inflammatory cytokine levels predicted subsequent cerebral palsy (CP) or neurodevelopmental delay (NDD).

RESULTS: Logistic regression analysis with 339 cases and 276 controls showed that elevated IL-8 and IL-1beta were more common in cord blood serum from infants with subsequent low MDI as compared with controls. After adjusting for additional confounders, the significant differences were no longer evident. Cytokine levels (IL-8, IL-1beta, and TNF-alpha) were not elevated with CP or low PDI.

STUDY DESIGN: Nested case-control analysis within a clinical trial of antenatal magnesium sulfate (MgSO4) before anticipated preterm birth (PTB) for prevention of CP, with evaluation of surviving children at the age of 2. NDD was defined as a Bayley psychomotor developmental index (PDI) and/or mental developmental index (MDI)<70. Controls, defined as surviving children without CP and with Bayley PDI and MDI>85, were matched by race and gestational age. Cord serum was analyzed for interleukin-8 (IL-8) interleukin-1 beta (IL-1beta), and tumor necrosis factor-alpha (TNF-alpha) levels. Elevated cytokine levels were defined as>75th percentile in placebo-exposed controls. Analyses compared case/control cytokine levels, adjusting for MgSO4 exposure, gestational age, race/ethnicity, and sociodemographic differences.

English

Powered by Koha