The utility of metformin therapy in reproductive-aged women with polycystic ovary syndrome (PCOS). [Review]

MedStar author(s):
Citation: Current Pharmaceutical Biotechnology. 15(1):70-83, 2014.PMID: 24720592Institution: MedStar Washington Hospital CenterDepartment: Medicine/EndocrinologyForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Hypoglycemic Agents/tu [Therapeutic Use] | *Metformin/tu [Therapeutic Use] | *Polycystic Ovary Syndrome/dt [Drug Therapy] | *Pregnancy Complications/dt [Drug Therapy] | Animals | Clomiphene/tu [Therapeutic Use] | Female | Fertility Agents, Female/tu [Therapeutic Use] | Humans | Hypoglycemic Agents/ae [Adverse Effects] | Hypoglycemic Agents/pd [Pharmacology] | Metformin/ae [Adverse Effects] | Metformin/pd [Pharmacology] | Nitriles/tu [Therapeutic Use] | Ovulation/de [Drug Effects] | Polycystic Ovary Syndrome/me [Metabolism] | Pregnancy | Pregnancy Complications/me [Metabolism] | Triazoles/tu [Therapeutic Use]ISSN:
  • 1389-2010
Name of journal: Current pharmaceutical biotechnologyAbstract: Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive- age women. With very little risk associated with its use, metformin provides many important benefits to women with PCOS, including regulating menstrual cycles, improving clinical signs of hyperandrogenism, ameliorating metabolic syndrome, inducing ovulation, improving pregnancy rates and pregnancy outcomes, preventing gestational diabetes, and preventing progression to T2DM. Here, we review the indications for metformin in women with PCOS, with a focus on the use of metformin during pre-conception and pregnancy.All authors: Nathan N, Sullivan SDDate added to catalog: 2015-04-29
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Journal Article MedStar Authors Catalog Article Available 24720592

Metformin, an insulin-sensitizing drug commonly used to treat Type 2 Diabetes Mellitus (T2DM), has been increasingly used off-label for the treatment of polycystic ovary syndrome (PCOS), which affects at least 5-10% of reproductive- age women. With very little risk associated with its use, metformin provides many important benefits to women with PCOS, including regulating menstrual cycles, improving clinical signs of hyperandrogenism, ameliorating metabolic syndrome, inducing ovulation, improving pregnancy rates and pregnancy outcomes, preventing gestational diabetes, and preventing progression to T2DM. Here, we review the indications for metformin in women with PCOS, with a focus on the use of metformin during pre-conception and pregnancy.

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