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Chronic mucosal inflammation/inflammatory bowel disease-like inflammation after intestinal transplantation: where are we now?. [Review]

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Citation: Current Opinion in Organ Transplantation. 19(3):276-80, 2014 Jun.PMID: 24752065Institution: MedStar Washington Hospital CenterDepartment: Surgery/TransplantationForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Inflammatory Bowel Diseases/et [Etiology] | *Intestinal Mucosa/im [Immunology] | *Intestines/tr [Transplantation] | *Postoperative Complications | Chronic Disease | Humans | Inflammatory Bowel Diseases/ge [Genetics] | Inflammatory Bowel Diseases/im [Immunology] | Nod2 Signaling Adaptor Protein/ge [Genetics] | Polymorphism, Single NucleotideISSN:

1087-2418

Name of journal: Current opinion in organ transplantationAbstract: PURPOSE OF REVIEW: The purpose of this review is to highlight the similarities between inflammatory bowel disease and the state of the intestine allograft after transplantation.RECENT FINDINGS: The mutant nucleotide-binding oligomerization protein 2 (NOD2) gene, which encodes for an intracellular protein that serves as an innate immune system microbial sensor in macrophages, dendritic cells, and certain intestinal epithelial cells, has been recognized as a risk factor in Crohn's disease. Similarly, recent studies have also highlighted the contribution the NOD2 mutation may have on intestinal failure itself. More specifically, in intestinal transplant recipients with the NOD2 mutation, the discovery of the reduced ability to prevent bacterial clearance, increased enterocyte stress response, and failure of key downstream expression of important cytokines and growth factors have been implicated as major factors in intestinal transplant outcomes, namely graft loss and septic death. Treatment strategies with anti tumor necrosis factor (TNF) alpha, similar to inflammatory bowel disease, have been employed in intestinal transplantation with promising results.SUMMARY: In intestinal transplantation, there is evidence that the classical alloimmunity pathways that lead toward graft dysfunction and eventual graft loss may, in fact, be working in concert with a disordered innate immune system to produce a state of chronic inflammation not unlike that seen in inflammatory bowel disease.All authors: Fishbein TM, Matsumoto CS, Zasloff MADigital Object Identifier:

http://dx.doi.org/10.1097/MOT.0000000000000077

Date added to catalog: 2014-08-21

Holdings ( 1 )
Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article		Available		24752065

PURPOSE OF REVIEW: The purpose of this review is to highlight the similarities between inflammatory bowel disease and the state of the intestine allograft after transplantation.

RECENT FINDINGS: The mutant nucleotide-binding oligomerization protein 2 (NOD2) gene, which encodes for an intracellular protein that serves as an innate immune system microbial sensor in macrophages, dendritic cells, and certain intestinal epithelial cells, has been recognized as a risk factor in Crohn's disease. Similarly, recent studies have also highlighted the contribution the NOD2 mutation may have on intestinal failure itself. More specifically, in intestinal transplant recipients with the NOD2 mutation, the discovery of the reduced ability to prevent bacterial clearance, increased enterocyte stress response, and failure of key downstream expression of important cytokines and growth factors have been implicated as major factors in intestinal transplant outcomes, namely graft loss and septic death. Treatment strategies with anti tumor necrosis factor (TNF) alpha, similar to inflammatory bowel disease, have been employed in intestinal transplantation with promising results.

SUMMARY: In intestinal transplantation, there is evidence that the classical alloimmunity pathways that lead toward graft dysfunction and eventual graft loss may, in fact, be working in concert with a disordered innate immune system to produce a state of chronic inflammation not unlike that seen in inflammatory bowel disease.

English