The effects of novel, bioresorbable scaffolds on coronary vascular pathophysiology. [Review]
Citation: Journal of Cardiovascular Translational Research . 7(4):413-25, 2014 Jun.PMID: 24800874Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Absorbable Implants | *Coronary Artery Disease/th [Therapy] | *Coronary Vessels/pp [Physiopathology] | *Percutaneous Coronary Intervention/is [Instrumentation] | *Stents | Animals | Coronary Artery Disease/di [Diagnosis] | Coronary Artery Disease/pp [Physiopathology] | Drug-Eluting Stents | Humans | Percutaneous Coronary Intervention/ae [Adverse Effects] | Prosthesis Design | Treatment OutcomeAbstract: Percutaneous coronary intervention (PCI) has rapidly evolved over the past 30 years as technology has sought to improve clinical outcomes by addressing pathophysiologic complications arising from the intervention. Stents were designed to resolve the drawbacks of balloon angioplasty by providing radial support to prevent vessel recoil, by sealing coronary dissections, and by preventing abrupt vessel closure. The conceptualization of an ideal drug-eluting fully bioresorbable scaffold (BRS), whether metallic or polymeric, would theoretically address the adverse aspects of permanent metallic stents. In this review of the literature, we will discuss the impact these novel fully BRS platforms have on vascular pathophysiology following PCI.Digital Object Identifier: Date added to catalog: 2015-03-17| Item type | Current library | Collection | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|---|
| Journal Article | MedStar Authors Catalog | Article | Available | 24800874 |
Percutaneous coronary intervention (PCI) has rapidly evolved over the past 30 years as technology has sought to improve clinical outcomes by addressing pathophysiologic complications arising from the intervention. Stents were designed to resolve the drawbacks of balloon angioplasty by providing radial support to prevent vessel recoil, by sealing coronary dissections, and by preventing abrupt vessel closure. The conceptualization of an ideal drug-eluting fully bioresorbable scaffold (BRS), whether metallic or polymeric, would theoretically address the adverse aspects of permanent metallic stents. In this review of the literature, we will discuss the impact these novel fully BRS platforms have on vascular pathophysiology following PCI.
English