Influenza and coronary artery disease: exploring a clinical association with myocardial infarction and analyzing the utility of vaccination in prevention of myocardial infarction. [Review]
Citation: Reviews in Cardiovascular Medicine. 15(2):168-75, 2014.PMID: 25051134Form of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Influenza Vaccines/ad [Administration & Dosage] | *Influenza, Human/pc [Prevention & Control] | *Myocardial Infarction/pc [Prevention & Control] | *Vaccination | Humans | Inflammation/im [Immunology] | Inflammation/pc [Prevention & Control] | Inflammation/vi [Virology] | Influenza, Human/di [Diagnosis] | Influenza, Human/ep [Epidemiology] | Influenza, Human/im [Immunology] | Influenza, Human/vi [Virology] | Myocardial Infarction/di [Diagnosis] | Myocardial Infarction/ep [Epidemiology] | Myocardial Infarction/im [Immunology] | Myocardial Infarction/vi [Virology] | Prognosis | Risk FactorsISSN:- 1530-6550
Item type | Current library | Collection | Call number | Status | Date due | Barcode |
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Journal Article | MedStar Authors Catalog | Article | Available | 25051134 |
Both coronary artery disease and influenza outbreaks contribute significantly to worldwide morbidity and mortality. An increasing number of epidemiologic studies have concluded that a temporal association exists between acute viral illnesses and myocardial infarction. Viral illnesses such as influenza can cause or exacerbate coronary atherosclerosis by activating inflammatory pathways. Data from a large case-controlled trial and two randomized controlled trials suggest that influenza vaccination in patients with coronary artery disease may lead to a decrease in incidence, morbidity, and mortality from acute myocardial infarction. A meta-analysis of the two randomized controlled trials for cardiovascular death demonstrated a pooled relative risk of 0.39 (95% confidence interval, 0.20-0.77) for patients who received the influenza vaccine compared with placebo.
English