Normal view MARC view ISBD view

Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives.

MedStar author(s):

Citation: Journal of the American College of Cardiology. 81(21):2059-2071, 2023 05 30.PMID: 37225358Institution: MedStar Health Research InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tSubject headings: *Cardiomyopathy, Dilated | Adult | Black People | Cardiomyopathy, Dilated/di [Diagnosis] | Cardiomyopathy, Dilated/ge [Genetics] | Echocardiography | Ethnicity | Female | Hispanic or Latino | Humans | Hypertrophy, Left Ventricular | Male | Middle Aged | Year: 2023 Local holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007ISSN:

0735-1097

Name of journal: Journal of the American College of CardiologyAbstract: BACKGROUND: Cardiovascular screening is recommended for first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for DCM patients without known familial DCM, for non-White FDRs, or for DCM partial phenotypes of left ventricular enlargement (LVE) or left ventricular systolic dysfunction (LVSD).CONCLUSIONS: Cardiovascular screening identified new DCM-related findings among 1 in 7 reportedly unaffected FDRs regardless of race and ethnicity, underscoring the value of clinical screening in all FDRs. Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.METHODS: Adult FDRs of DCM patients at 25 sites completed screening echocardiograms and ECGs. Mixed models accounting for site heterogeneity and intrafamilial correlation were used to compare screen-based percentages of DCM, LVSD, or LVE by FDR demographics, cardiovascular risk factors, and proband genetics results.OBJECTIVES: This study examined the yield of clinical screening among reportedly unaffected FDRs of DCM patients.RESULTS: A total of 1,365 FDRs were included, with a mean age of 44.8 +/- 16.9 years, 27.5% non-Hispanic Black, 9.8% Hispanic, and 61.7% women. Among screened FDRs, 14.1% had new diagnoses of DCM (2.1%), LVSD (3.6%), or LVE (8.4%). The percentage of FDRs with new diagnoses was higher for those aged 45 to 64 years than 18 to 44 years. The age-adjusted percentage of any finding was higher among FDRs with hypertension and obesity but did not differ statistically by race and ethnicity (16.2% for Hispanic, 15.2% for non-Hispanic Black, and 13.1% for non-Hispanic White) or sex (14.6% for women and 12.8% for men). FDRs whose probands carried clinically reportable variants were more likely to be identified with DCM.All authors: Cao J, Ewald GA, Fishbein DP, Garg S, Gottlieb SS, Haas GJ, Hershberger RE, Hofmeyer M, Huggins GS, Jimenez J, Jordan E, Judge DP, Katz S, Kinnamon DD, Kransdorf E, Lowes B, Moore CK, Morris AA, Ni H, Owens A, Pamboukian SV, Pan S, Shah P, Smart F, Stoller D, Sweitzer NK, Tang WHW, Trachtenberg BH, Wang J, Wheeler MT, Wilcox JEFiscal year: FY2023 Digital Object Identifier:

https://dx.doi.org/10.1016/j.jacc.2023.03.419

Date added to catalog: 2023-07-27

Holdings ( 1 )
Title notes ( 7 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	37225358	Available		37225358

Available online from MWHC library: 1995 - present, Available in print through MWHC library:1999-2007

BACKGROUND: Cardiovascular screening is recommended for first-degree relatives (FDRs) of patients with dilated cardiomyopathy (DCM), but the yield of FDR screening is uncertain for DCM patients without known familial DCM, for non-White FDRs, or for DCM partial phenotypes of left ventricular enlargement (LVE) or left ventricular systolic dysfunction (LVSD).

CONCLUSIONS: Cardiovascular screening identified new DCM-related findings among 1 in 7 reportedly unaffected FDRs regardless of race and ethnicity, underscoring the value of clinical screening in all FDRs. Copyright © 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

METHODS: Adult FDRs of DCM patients at 25 sites completed screening echocardiograms and ECGs. Mixed models accounting for site heterogeneity and intrafamilial correlation were used to compare screen-based percentages of DCM, LVSD, or LVE by FDR demographics, cardiovascular risk factors, and proband genetics results.

OBJECTIVES: This study examined the yield of clinical screening among reportedly unaffected FDRs of DCM patients.

RESULTS: A total of 1,365 FDRs were included, with a mean age of 44.8 +/- 16.9 years, 27.5% non-Hispanic Black, 9.8% Hispanic, and 61.7% women. Among screened FDRs, 14.1% had new diagnoses of DCM (2.1%), LVSD (3.6%), or LVE (8.4%). The percentage of FDRs with new diagnoses was higher for those aged 45 to 64 years than 18 to 44 years. The age-adjusted percentage of any finding was higher among FDRs with hypertension and obesity but did not differ statistically by race and ethnicity (16.2% for Hispanic, 15.2% for non-Hispanic Black, and 13.1% for non-Hispanic White) or sex (14.6% for women and 12.8% for men). FDRs whose probands carried clinically reportable variants were more likely to be identified with DCM.

English