Angiography-Derived and Sensor-Wire Methods to Assess Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarction. [Review]

MedStar author(s):
Citation: Jacc: Cardiovascular Imaging. 16(7):965-981, 2023 07.PMID: 37052555Institution: MedStar Heart & Vascular InstituteForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Myocardial Infarction | *Percutaneous Coronary Intervention | *ST Elevation Myocardial Infarction | Coronary Angiography | Coronary Circulation | Coronary Vessels/dg [Diagnostic Imaging] | Humans | Microcirculation | Myocardial Infarction/dg [Diagnostic Imaging] | Myocardial Infarction/th [Therapy] | Predictive Value of Tests | ST Elevation Myocardial Infarction/dg [Diagnostic Imaging] | ST Elevation Myocardial Infarction/th [Therapy] | Treatment Outcome | Year: 2023ISSN:
  • 1876-7591
Name of journal: JACC. Cardiovascular imagingAbstract: ST-segment elevation myocardial infarction (STEMI) treatment with primary percutaneous coronary intervention has dramatically impacted prognosis. However, despite satisfactory angiographic result, occurrence or persistence of coronary microvascular dysfunction after revascularization still affects long-term outcomes. The diagnostic and therapeutic value of understanding the status of coronary microcirculation is gaining attention in the cardiology community. However, current methods to assess microvascular function (namely, cardiac magnetic resonance and invasive wire-based coronary physiology) remain, at least in part, limited by technical and logistic aspects. On the other hand, angiography-based indices of microcirculatory resistance are emerging as valid and user-friendly tools with potential impact on prognostic stratification of patients with STEMI. This review provides an overview about conventional and novel methods to assess coronary microvascular dysfunction in patients with STEMI. The authors also provide a proposed procedural algorithm to facilitate optimal use of wire-based and angiography-based indices in the acute setting of STEMI. Copyright 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.All authors: Banning AP, De Maria GL, Della Mora F, Garcia Garcia HM, Levine MB, Mainardi A, Marin F, Portolan L, Ribichini F, Ruzzarin A, Scarsini ROriginally published: Original year of publication: 2023Fiscal year: Fiscal year of original publication: FY2023Digital Object Identifier:
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Journal Article MedStar Authors Catalog Article 37052555 Available 37052555

ST-segment elevation myocardial infarction (STEMI) treatment with primary percutaneous coronary intervention has dramatically impacted prognosis. However, despite satisfactory angiographic result, occurrence or persistence of coronary microvascular dysfunction after revascularization still affects long-term outcomes. The diagnostic and therapeutic value of understanding the status of coronary microcirculation is gaining attention in the cardiology community. However, current methods to assess microvascular function (namely, cardiac magnetic resonance and invasive wire-based coronary physiology) remain, at least in part, limited by technical and logistic aspects. On the other hand, angiography-based indices of microcirculatory resistance are emerging as valid and user-friendly tools with potential impact on prognostic stratification of patients with STEMI. This review provides an overview about conventional and novel methods to assess coronary microvascular dysfunction in patients with STEMI. The authors also provide a proposed procedural algorithm to facilitate optimal use of wire-based and angiography-based indices in the acute setting of STEMI. Copyright 2023 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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