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The relationship between subclinical atherosclerosis, non-high-density lipoprotein cholesterol, exercise, anddiet among male participants of the PACC Project.

MedStar author(s):

1876-4789

Name of journal: Journal of clinical lipidologyAbstract: BACKGROUND: Non-high-density lipoprotein (HDL) cholesterol is recommended as a secondary lipid goal treated initially with lifestyle modification. However, the relationship between non-HDL and subclinical atherosclerosis is unknown. We examined the independent relationships between coronary artery calcium (CAC), lipids including non-HDL, exercise, and diet among healthy male participants of the Prospective Army Coronary Calcium (PACC) Project.CONCLUSIONS: Non-HDL-C and exercise are independently predictive of the presence of subclinical CAC among healthy lower-risk middle-aged men. Copyright A 2012 National Lipid Association. All rights reserved.METHODS: Male participants from the PACC Project (n= 1637, mean age 42.8 years; no history of coronary heart disease) were studied. We used validated surveys to measure dietary quality and habitual physical exercise. Fasting lipid concentrations and other cardiovascular risk variables were measured. Subclinical atherosclerosis was detected with the use of electron beam computed tomography for CAC. Factors independently associated with the presence of any detectable CAC (CAC score > 0), including standard CV risk variables, non-HDL, exercise, and diet, were evaluated with the use of logistic regression.RESULTS: The mean Framingham risk score was 4.6 +/- 2.6%; CAC was present in 22.4%. Fasting lipid concentrations showed mean LDL-C 128 +/- 32 mg/dL, HDL-C 50 +/- 13 mg/dL, TG-C 130 +/- 86 mg/dL, and non-HDL-C 154 +/- 37 mg/dL. Men with CAC had significantly greater levels of LDL-C (135 vs 127 mg/dL), TG (148 vs 124 mg/dL), and non-HDL-C (164 vs 151 mg/dL) and less habitual physical activity (P= 0.006). There were nonsignificant trends between prevalent CAC, greater amounts of dietary fat intake, and lower HDL-C. In successive multivariable logistic regression models for the dependent variable CAC, only non-HDL-C (odds ratio [OR] 1.012 per mg/dL; 95% CI 1.002-1.023; P= .019) and age (OR 1.119 per year; 95% CI 1.063-1.178; P < .001) were independently associated with the presence of CAC, and exercise (OR 0.808; 95% CI 0.703-0.928; P= 0.003) was associated with the absence of CAC.All authors: Rich M, Simprini LA, Taylor AJ, Villines TCFiscal year: FY2012Digital Object Identifier:

http://dx.doi.org/10.1016/j.jacl.2011.11.005

Date added to catalog: 2013-09-17

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	22385551	Available		22385551

BACKGROUND: Non-high-density lipoprotein (HDL) cholesterol is recommended as a secondary lipid goal treated initially with lifestyle modification. However, the relationship between non-HDL and subclinical atherosclerosis is unknown. We examined the independent relationships between coronary artery calcium (CAC), lipids including non-HDL, exercise, and diet among healthy male participants of the Prospective Army Coronary Calcium (PACC) Project.

CONCLUSIONS: Non-HDL-C and exercise are independently predictive of the presence of subclinical CAC among healthy lower-risk middle-aged men. Copyright A 2012 National Lipid Association. All rights reserved.

METHODS: Male participants from the PACC Project (n= 1637, mean age 42.8 years; no history of coronary heart disease) were studied. We used validated surveys to measure dietary quality and habitual physical exercise. Fasting lipid concentrations and other cardiovascular risk variables were measured. Subclinical atherosclerosis was detected with the use of electron beam computed tomography for CAC. Factors independently associated with the presence of any detectable CAC (CAC score > 0), including standard CV risk variables, non-HDL, exercise, and diet, were evaluated with the use of logistic regression.

RESULTS: The mean Framingham risk score was 4.6 +/- 2.6%; CAC was present in 22.4%. Fasting lipid concentrations showed mean LDL-C 128 +/- 32 mg/dL, HDL-C 50 +/- 13 mg/dL, TG-C 130 +/- 86 mg/dL, and non-HDL-C 154 +/- 37 mg/dL. Men with CAC had significantly greater levels of LDL-C (135 vs 127 mg/dL), TG (148 vs 124 mg/dL), and non-HDL-C (164 vs 151 mg/dL) and less habitual physical activity (P= 0.006). There were nonsignificant trends between prevalent CAC, greater amounts of dietary fat intake, and lower HDL-C. In successive multivariable logistic regression models for the dependent variable CAC, only non-HDL-C (odds ratio [OR] 1.012 per mg/dL; 95% CI 1.002-1.023; P= .019) and age (OR 1.119 per year; 95% CI 1.063-1.178; P < .001) were independently associated with the presence of CAC, and exercise (OR 0.808; 95% CI 0.703-0.928; P= 0.003) was associated with the absence of CAC.

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