Citation: Nature Genetics. 41(11):1182-90, 2009 Nov..Journal: Nature genetics.ISSN: 1546-1718.Full author list: Soranzo N; Spector TD; Mangino M; Kuhnel B; Rendon A; Teumer A; Willenborg C; Wright B; Chen L; Li M; Salo P; Voight BF; Burns P; Laskowski RA; Xue Y; Menzel S; Altshuler D; Bradley JR; Bumpstead S; Burnett MS; Devaney J; Doring A; Elosua R; Epstein SE; Erber W; Falchi M; Garner SF; Ghori MJ; Goodall AH; Gwilliam R; Hakonarson HH; Hall AS; Hammond N; Hengstenberg C; Illig T; Konig IR; Knouff CW; McPherson R; Melander O; Mooser V; Nauck M; Nieminen MS; O'Donnell CJ; Peltonen L; Potter SC; Prokisch H; Rader DJ; Rice CM; Roberts R; Salomaa V; Sambrook J; Schreiber S; Schunkert H; Schwartz SM; Serbanovic-Canic J; Sinisalo J; Siscovick DS; Stark K; Surakka I; Stephens J; Thompson JR; Volker U; Volzke H; Watkins NA; Wells GA; Wichmann HE; Van Heel DA; Tyler-Smith C; Thein SL; Kathiresan S; Perola M; Reilly MP; Stewart AF; Erdmann J; Samani NJ; Meisinger C; Greinacher A; Deloukas P; Ouwehand WH; Gieger C.UI/PMID: 19820697.Subject(s): Blood Cell Count | Blood Cells/cy [Cytology] | *Blood Cells | Chromosomes, Human, Pair 12 | Coronary Artery Disease/ge [Genetics] | Genetic Markers | *Genome, Human | *Genome-Wide Association Study | Humans | Polymorphism, Single Nucleotide | Selection, GeneticInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Meta-Analysis | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov'tDigital Object Identifier: http://dx.doi.org/10.1038/ng.467 (Click here)Abbreviated citation: Nat Genet. 41(11):1182-90, 2009 Nov.Abstract: The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.