Citation: Diabetes Care. 34(10):2300-5, 2011 Oct..Journal: Diabetes; Diabetes care.ISSN: 0149-5992.Full author list: De Marco M; de Simone G; Roman MJ; Chinali M; Lee ET; Calhoun D; Howard BV; Devereux RB.UI/PMID: 21873564.Subject(s): Adolescent | Adult | Diabetes Mellitus/ep [Epidemiology] | *Diabetes Mellitus/pp [Physiopathology] | Echocardiography | Female | Hemodynamics | Humans | Hypertension/ep [Epidemiology] | Hypertension/et [Etiology] | Hypertrophy, Left Ventricular/ep [Epidemiology] | Hypertrophy, Left Ventricular/et [Etiology] | Male | Prediabetic State/ep [Epidemiology] | *Prediabetic State/pp [Physiopathology] | Ventricular Function, Left/ph [Physiology] | Young AdultInstitution(s): MedStar Health Research InstituteActivity type: Journal Article.Medline article type(s): Journal Article | Research Support, N.I.H., ExtramuralOnline resources: Click here to access onlineDigital Object Identifier: http://dx.doi.org/10.2337/dc11-0191 (Click here)Abbreviated citation: Diabetes Care. 34(10):2300-5, 2011 Oct.Local Holdings: Available online from MWHC library: 1995 - present, Available in print through MWHC library: 1999 - 2006.Abstract: OBJECTIVE: The aim of this study was to evaluate whether diabetes (DM) and impaired fasting glucose (IFG) were associated with early alterations in left ventricular geometry and function in a large population of adolescents and young adults independently of major confounders.Abstract: RESEARCH DESIGN AND METHODS: We analyzed echocardiographic data of 1,624 14- to 39-year-old participants (mean age 26.6 +/- 7.7 years; 57% female) without prevalent cardiovascular disease from the fourth Strong Heart Study examination; 179 (11%) participants had DM and 299 (18%) had IFG.Abstract: RESULTS: Participants with DM and IFG were older and more often obese and hypertensive than participants with normal fasting glucose (NFG) (all P < 0.05). After adjustment for age, sex, systolic blood pressure, and body fat, diabetic and IFG participants had higher left ventricular mass index than those with NFG (41.5 +/- 8.7 and 39.6 +/- 9.2 vs. 35.6 +/- 7.8 g/m(2.7)) and reduced stress-corrected midwall shortening (98 +/- 8.6 and 99 +/- 7.5 vs. 101 +/- 8.5%; all P < 0.05). The prevalence of left ventricular hypertrophy was higher in DM (20%) and IFG (17%) than in NFG participants (12%; P < 0.05). Compared with the other groups, DM was also associated with higher prevalence of inappropriate left ventricular mass, concentric geometry, and more diastolic abnormalities independently of covariates (all P < 0.05).Abstract: CONCLUSIONS: In a population of adolescents and young adults, DM is independently associated with early unfavorable cardiovascular phenotype characterized by increased left ventricular mass, concentric geometry, and early preclinical systolic and diastolic dysfunction; early cardiovascular alterations are also present in participants with prediabetes.