Importance of gender in diffuse malignant peritoneal mesothelioma.

MedStar author(s):
Citation: Annals of Oncology. 23(6):1494-8, 2012 Jun.PMID: 22056853Institution: MedStar Washington Hospital CenterDepartment: Surgery/General SurgeryForm of publication: Journal ArticleMedline article type(s): Journal Article | Multicenter StudySubject headings: *Mesothelioma/th [Therapy] | *Peritoneal Neoplasms/th [Therapy] | Adult | Antineoplastic Agents/ad [Administration & Dosage] | Combined Modality Therapy | Female | Humans | Injections, Intraperitoneal | Kaplan-Meier Estimate | Lymphatic Metastasis | Male | Mesothelioma/mo [Mortality] | Mesothelioma/sc [Secondary] | Middle Aged | Peritoneal Neoplasms/mo [Mortality] | Peritoneal Neoplasms/pa [Pathology] | Prognosis | Sex Factors | Treatment OutcomeYear: 2012Local holdings: Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1999 - 2006ISSN:
  • 0923-7534
Name of journal: Annals of oncology : official journal of the European Society for Medical Oncology / ESMOAbstract: BACKGROUND: Combined therapy involving cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy has been shown to improve survival outcomes for patients with diffuse malignant peritoneal mesothelioma (DMPM). The present study aims to investigate gender as a potential prognostic factor on overall survival.CONCLUSIONS: Gender has demonstrated a significant impact on overall survival for patients with DMPM after CRS and perioperative intraperitoneal chemotherapy. An improved understanding of the role of estrogen in the pathogenesis of DMPM may improve the prognostication of patients and determine the role of adjuvant hormonal treatment in the future.PATIENTS AND METHODS: Over a period of two decades, 294 patients who underwent CRS and perioperative intraperitoneal chemotherapy were selected from a large multi-institutional registry to assess the prognostic significance of gender on overall survival.RESULTS: Female patients were shown to have a significantly improved survival outcome than male patients (P < 0.001). Staging according to a recently proposed tumor-node-metastasis categorization system was significant in both genders. Older female patients had significantly worse survival than younger female patients (P = 0.019), a finding that was absent in male patients. Female patients with low-stage disease were found to have a very favorable long-term outcome after combined treatment.All authors: Cao C, Chua TC, Deraco M, Elias D, Glehen O, Levine EA, Moran BJ, Morris DL, Peritoneal Surface Malignancy Group, Piso P, Sugarbaker PH, Yan TDFiscal year: FY2012Digital Object Identifier: Date added to catalog: 2013-09-17
Holdings
Item type Current library Collection Call number Status Date due Barcode
Journal Article MedStar Authors Catalog Article 22056853 Available 22056853

Available online from MWHC library: 1996 - present, Available in print through MWHC library: 1999 - 2006

BACKGROUND: Combined therapy involving cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy has been shown to improve survival outcomes for patients with diffuse malignant peritoneal mesothelioma (DMPM). The present study aims to investigate gender as a potential prognostic factor on overall survival.

CONCLUSIONS: Gender has demonstrated a significant impact on overall survival for patients with DMPM after CRS and perioperative intraperitoneal chemotherapy. An improved understanding of the role of estrogen in the pathogenesis of DMPM may improve the prognostication of patients and determine the role of adjuvant hormonal treatment in the future.

PATIENTS AND METHODS: Over a period of two decades, 294 patients who underwent CRS and perioperative intraperitoneal chemotherapy were selected from a large multi-institutional registry to assess the prognostic significance of gender on overall survival.

RESULTS: Female patients were shown to have a significantly improved survival outcome than male patients (P < 0.001). Staging according to a recently proposed tumor-node-metastasis categorization system was significant in both genders. Older female patients had significantly worse survival than younger female patients (P = 0.019), a finding that was absent in male patients. Female patients with low-stage disease were found to have a very favorable long-term outcome after combined treatment.

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