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The presentation, etiologies, pathophysiology, and treatment of pulmonary renal syndrome: A review of the literature. [Review]

MedStar author(s):

, Internal Medicine & Pediatrics Residency

Citation: Disease-A-Month. 68(12):101465, 2022 Dec.PMID: 36008166Department: Internal Medicine & Pediatrics Residency | MedStar Georgetown University Hospital/MedStar Washington Hospital CenterForm of publication: Journal ArticleMedline article type(s): Journal Article | ReviewSubject headings: *Anti-Glomerular Basement Membrane Disease | *Glomerulonephritis | *Lung Diseases | Anti-Glomerular Basement Membrane Disease/co [Complications] | Anti-Glomerular Basement Membrane Disease/di [Diagnosis] | Antibodies, Antineutrophil Cytoplasmic/tu [Therapeutic Use] | Glomerulonephritis/di [Diagnosis] | Glomerulonephritis/et [Etiology] | Glomerulonephritis/th [Therapy] | Hemorrhage/di [Diagnosis] | Hemorrhage/et [Etiology] | Hemorrhage/th [Therapy] | Humans | Immunosuppressive Agents/tu [Therapeutic Use] | Lung Diseases/di [Diagnosis] | Lung Diseases/et [Etiology] | Lung Diseases/th [Therapy]Year: 2022 Local holdings: Available online from MWHC library: 2001 - presentISSN:

0011-5029

Name of journal: Disease-a-month : DMAbstract: Pulmonary renal syndrome (PRS) is a constellation of different disorders that cause both rapidly progressive glomerulonephritis and diffuse alveolar hemorrhage. While antineutrophil cytoplasmic antibody associated vasculitis and anti-glomerular basement membrane disease are the predominant causes of PRS, numerous other mechanisms have been shown to cause this syndrome, including thrombotic microangiopathies, drug exposures, and infections, among others. This syndrome has high morbidity and mortality, and early diagnosis and treatment is imperative to improve outcomes. Treatment generally involves glucocorticoids and immunosuppressive agents, but treatment targeted to the underlying disorder can improve outcomes and mitigate side effects. Familiarity with the wide range of possible causes of PRS can aid the clinician in workup, diagnosis and early initiation of treatment. This review provides a summary of the clinical presentation, etiologies, pathophysiology, and treatment of PRS. Copyright © 2022 Elsevier Inc. All rights reserved.All authors: Cunningham M, Deleveaux S, Lerma E, Madariaga H, Martin K, Ramaswamy K, Thomas BFiscal year: FY2023 Digital Object Identifier:

https://dx.doi.org/10.1016/j.disamonth.2022.101465

Date added to catalog: 2022-12-13

Holdings ( 1 )
Title notes ( 3 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	36008166	Available		36008166

Available online from MWHC library: 2001 - present

Pulmonary renal syndrome (PRS) is a constellation of different disorders that cause both rapidly progressive glomerulonephritis and diffuse alveolar hemorrhage. While antineutrophil cytoplasmic antibody associated vasculitis and anti-glomerular basement membrane disease are the predominant causes of PRS, numerous other mechanisms have been shown to cause this syndrome, including thrombotic microangiopathies, drug exposures, and infections, among others. This syndrome has high morbidity and mortality, and early diagnosis and treatment is imperative to improve outcomes. Treatment generally involves glucocorticoids and immunosuppressive agents, but treatment targeted to the underlying disorder can improve outcomes and mitigate side effects. Familiarity with the wide range of possible causes of PRS can aid the clinician in workup, diagnosis and early initiation of treatment. This review provides a summary of the clinical presentation, etiologies, pathophysiology, and treatment of PRS. Copyright © 2022 Elsevier Inc. All rights reserved.

English