Name of journal: European heart journal. Cardiovascular ImagingAbstract: AIMS: To assess the impact of the baseline plaque composition on the DREAMS 3G luminal late loss and to compare the serial plaque changes between baseline and 6-month (6 M), and 12-month (12 M) follow-up.CONCLUSIONS: The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 M and 12 M. Following the implantation of DREAMS 3G, favorable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue. Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: [email protected] AND RESULTS: A total of 116 patients were enrolled in the BIOMAG-I trial. Patients were imaged with optical coherence tomography (OCT) pre- and post-DREAMS 3G implantation and at 6 and 12 months. OCTPlus software uses artificial intelligence to assess composition (i.e., lipid, calcium, fibrous tissue) of the plaque. The differences between the OCT-derived minimum lumen area (MLA) post-percutaneous coronary intervention (PCI) and 12 M, were grouped into 3 terciles. Patients with larger MLA differences at 12 M (p 0.0003) had significantly larger content of fibrous tissue at baseline. There was a reduction of 24.8% and 20.9% in lipid area, both p < 0.001, between the pre-DREAMS 3G OCT and the 6 M and 12 M follow-up. Conversely, the fibrous tissue increased by 48.4% and 36.0% at 6 M and 12 M follow-up, both p < 0.001.All authors: Garcia-Garcia HM, Waksman R, Melaku GD, Garg M, Beyene S, Wlodarczak A, Kerai A, Levine MB, van der Schaaf RJ, Torzewski J, Ferdinande B, Escaned J, Iglesias JF, Bennett J, Toth GG, Joner M, Toelg R, Wiemer M, Olivecrona G, Vermeersch P, Haude MFiscal year: FY2024 Digital Object Identifier:

https://dx.doi.org/10.1093/ehjci/jead299

ORCID:

https://orcid.org/0000-0001-5100-0471

Date added to catalog: 2024-01-22

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Title notes ( 4 )

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Journal Article	MedStar Authors Catalog	Article	37936296	Available		37936296

AIMS: To assess the impact of the baseline plaque composition on the DREAMS 3G luminal late loss and to compare the serial plaque changes between baseline and 6-month (6 M), and 12-month (12 M) follow-up.

CONCLUSIONS: The larger the fibrous tissue in the lesion at baseline, the larger the luminal loss seen at 6 M and 12 M. Following the implantation of DREAMS 3G, favorable healing of the vessel coronary wall occurs as shown by a decrease in the lipid area and an increase in fibrous tissue. Copyright © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: [email protected].

METHODS AND RESULTS: A total of 116 patients were enrolled in the BIOMAG-I trial. Patients were imaged with optical coherence tomography (OCT) pre- and post-DREAMS 3G implantation and at 6 and 12 months. OCTPlus software uses artificial intelligence to assess composition (i.e., lipid, calcium, fibrous tissue) of the plaque. The differences between the OCT-derived minimum lumen area (MLA) post-percutaneous coronary intervention (PCI) and 12 M, were grouped into 3 terciles. Patients with larger MLA differences at 12 M (p 0.0003) had significantly larger content of fibrous tissue at baseline. There was a reduction of 24.8% and 20.9% in lipid area, both p < 0.001, between the pre-DREAMS 3G OCT and the 6 M and 12 M follow-up. Conversely, the fibrous tissue increased by 48.4% and 36.0% at 6 M and 12 M follow-up, both p < 0.001.

English